From: The challenges for molecular nutrition research 1: linking genotype to healthy nutrition
The challenges of molecular nutrition research | ||
---|---|---|
1 | Linking genotype to healthy nutrition | Genomic variation predisposes for diet related diseases and provides opportunities for tailored prevention. Inclusion of diet in genetic research is thus essential and strategies are discussed |
2 | Quantification of the nutritional phenotype | Methods to quantify the healthy instead of the (pre)disease phenotype in relation to nutrition are introduced and discussed |
3 | Comparative nutrigenomics | The goal of model systems (yeast, c elegance, mice, ...) in comparative nutrigenomics studies is to identify the modular architecture controlling nutritional processes and identify the players that cause a system to drive away from equilibrium into instabilities and to allow the system to reach a new steady state of metabolic adaptation |
4 | Nutritional systems biology | Can we systematically study the molecular mechanisms underlying the metabolic adaptation at the cellular, organ and whole organism level and take it onto the level of modeling? |
5 | Quantification of food intake | New analytical technologies quantify the “food metabolome” and may link the descriptive intake methods (like food frequency questionnaires) to the more exact methods used in nutritional intervention studies |
6 | Technology and informatics | Nutrition research is now embedded in a variety of technology revolutions. This requires nutrition research specific fine-tuning, standardisation, annotation, databasing and (bio)informatics. An integrated approach is presented |