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Fig. 1 | Genes & Nutrition

Fig. 1

From: Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat

Fig. 1

Effect of type 2 diabetes genetic predisposition score (T2D-GPS) on insulin sensitivity (Si), acute insulin secretion (AIRg) and disposition index (DI) at baseline. The participants were stratified by T2D-GPS, and the number of participants in each GPS stratum is shown in panel d. The effect of T2D-GPS on (a) Insulin sensitivity index (Si) (b) Acute insulin secretion (AIRg) and (c) Disposition index (DI) is presented as geometric mean and 95% CI. Data were log(n)-transformed for analysis, and the per allele effect was determined by linear regression analysis with age, gender, BMI and centre as confounding variables. The effect is presented as the beta-coefficient from the linear regression of the log(n)-transformed trait (which equated to percentage difference) and the P value. These measures were conducted after a 1-month period on a ‘reference’ high SFA diet prior to the dietary intervention to lower SFA intake

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Genes & Nutrition

ISSN: 1865-3499

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