Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat

Walker, Celia G.; Loos, Ruth J. F.; Mander, Adrian P.; Jebb, Susan A.; Frost, Gary S.; Griffin, Bruce A.; Lovegrove, Julie A.; Sanders, Thomas A. B.; Bluck, Les J.

doi:10.1007/s12263-012-0284-8

Table 2 T2D-SNPs that compose the GPS and the association with insulin sensitivity (Si), insulin secretion (AIRg) and disposition index (DI) at baseline

From: Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat

SNP	Near gene	Location/type	Risk Allele for T2D	Risk-allele Frequency	Insulin sensitivity (Si)			Insulin secretion (AIRg)			Disposition index (DI)
SNP	Near gene	Location/type	Risk Allele for T2D	Risk-allele Frequency	Effect of risk allele	SE	P	Effect of risk allele	SE	P	Effect of risk allele	SE	P
rs4607103	ADAMTS9	Intergenic	C	0.72	−0.10	0.04	0.01	0.04	0.07	0.57	−0.06	0.07	0.45
rs243021	BCL11A	Intergenic	A	0.47	−0.03	0.04	0.38	−0.02	0.06	0.75	−0.05	0.06	0.44
rs7754840	CDKAL1	Intron	C	0.30	0.06	0.04	0.15	−0.02	0.07	0.77	0.03	0.07	0.66
rs10811661	CDKN2A/B	Intergenic	T	0.84	0.01	0.05	0.80	0.05	0.08	0.50	0.07	0.08	0.41
rs1552224	CENTD2	Intergenic	A	0.86	−0.02	0.05	0.74	0.04	0.08	0.62	0.03	0.09	0.75
rs9939609	FTO	Intron	A	0.39	0.03	0.04	0.48	−0.07	0.06	0.25	−0.05	0.07	0.41
rs780094	GCKR	Intron	C	0.36	−0.01	0.04	0.76	−0.03	0.06	0.59	−0.04	0.06	0.50
rs1111875	HHEX/IDE	Intergenic	C	0.59	0.01	0.04	0.88	−0.06	0.06	0.38	−0.06	0.07	0.40
rs1531343	HMGA2	Intergenic	C	0.12	−0.06	0.06	0.31	−0.04	0.10	0.72	−0.11	0.11	0.31
rs7957197	HNF1A	Intron	T	0.16	−0.03	0.05	0.48	−0.10	0.08	0.20	−0.13	0.08	0.11
rs4430796	HNF1B(TCF2)	Intron	G	0.05	0.00	0.03	0.93	−0.07	0.06	0.22	−0.07	0.06	0.22
rs7578326	IRS1	Intergenic	A	0.66	−0.05	0.04	0.24	0.01	0.07	0.84	−0.02	0.07	0.73
rs864745	JAZF1	Intron	T	0.55	−0.08	0.04	0.02	−0.06	0.06	0.33	−0.15	0.06	0.02
rs5215	KCNJ11	Missense	C	0.35	0.03	0.04	0.38	0.04	0.06	0.55	0.06	0.06	0.33
rs231362	KCNQ1	Intron	G	0.59	0.05	0.03	0.13	−0.05	0.05	0.34	−0.00	0.05	0.96
rs163184	KCNQ1	Intron	G	0.46	−0.03	0.04	0.35	−0.04	0.06	0.53	−0.07	0.06	0.27
rs1387153	MTNR1B	Intergenic	T	0.29	0.02	0.04	0.60	−0.09	0.07	0.19	−0.06	0.07	0.37
rs10923931	NOTCH2	Intron	T	0.14	−0.02	0.06	0.76	−0.14	0.10	0.17	−0.17	0.10	0.11
rs1801282	PPARG	Missense	C	0.91	−0.03	0.06	0.58	0.20	0.10	0.05	0.18	0.11	0.09
rs7901695	TCF7L2	Intron	C	0.32	0.04	0.04	0.36	−0.26	0.06	0.00005	−0.23	0.07	0.001
rs7578597	THADA	Missense	T	0.88	−0.04	0.05	0.48	0.11	0.09	0.26	0.07	0.10	0.48
rs7961581	TSPAN8/LGR5	Intergenic	C	0.25	0.03	0.04	0.43	0.02	0.07	0.82	0.04	0.08	0.64
rs1801214	WFS1	Missense	T	0.59	−0.06	0.04	0.12	0.03	0.06	0.63	−0.03	0.06	0.61
rs4457053	ZBED3	Intergenic	G	0.31	0.04	0.04	0.21	−0.07	0.06	0.26	−0.03	0.06	0.66
rs11634397	ZFAND6	Intergenic	G	0.63	−0.01	0.04	0.83	−0.00	0.07	0.94	−0.02	0.07	0.79

Data are the coefficient of associations presented as per allele effect size, standard error and P derived from linear regression models. The linear regression models were of SNP against Si, AIRg or DI at baseline adjusted for age, gender, BMI and centre. Data for Si, AIRg and DI were log(n)-transformed for analysis and are presented in this form

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ISSN: 1865-3499

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