Interactions between meat intake and genetic variation in relation to colorectal cancer

Andersen, Vibeke; Vogel, Ulla

doi:10.1007/s12263-014-0448-9

Genes & Nutrition

Table 1 Interactions between meat intake and polymorphisms in relation to the risk of colorectal cancer in prospective cohorts

From: Interactions between meat intake and genetic variation in relation to colorectal cancer

Gene	rs-number^d			N _cases	N _sub-cohort	IRR/OR (95 % CI)^a	P ^b_int	Comments^c	First author	Year	References
Cooking carcinogens and mutagens
NAT1			Slow	120	123			4	Chen	1998	Chen et al. (1998)
		NAT*10 allele	Rapid	92	98		0.19	4			Chen et al. (1998)
NAT2			Slow	131	125			4			Chen et al. (1998)
			Rapid	81	96		0.56	4			Chen et al. (1998)
NAT2			Slow	107	267			5	Chan	2005	Chan et al. (2005)
			Rapid	76	476		0.07	5			Chan et al. (2005)
NAT1			Slow			0.99 (0.94–1.04)		2, 3, 6	Sorensen	2008	Sorensen et al. (2008)
			Fast			0.98 (0.90–1.05)	>0.40	2, 3, 6			Sorensen et al. (2008)
NAT2			Slow			1.00 (0.95–1.06)		2, 3, 6			Sorensen et al. (2008)
			Fast			0.96 (0.90–1.03)	>0.40	2, 3, 6			Sorensen et al. (2008)
NAT1			No*10	362	527			7	Nothlings	2009	Nothlings et al. (2009)
			*10	482	818		0.77	7			Nothlings et al. (2009)
NAT2			Slow/med	750	1149			7			Nothlings et al. (2009)
			Rapid	242	344		0.44	7			Nothlings et al. (2009)
NAT1			No*10	362	527			8			Nothlings et al. (2009)
			*10	482	818		0.93	8			Nothlings et al. (2009)
NAT2			Slow/med	750	1,149			8			Nothlings et al. (2009)
			Rapid	242	344		0.13	8			Nothlings et al. (2009)
AHR	rs2066853			364	394		0.07	12	Gilsing	2012	Gilsing et al. (2012)
UGT1A	rs6714486			364	394		0.06	12			Gilsing et al. (2012)
	rs17868299			364	394		0.05	12			Gilsing et al. (2012)
UGT1A	rs2011404			364	394		0.08	12			Gilsing et al. (2012)
CYP2E1	rs915908			364	394		0.05	12			Gilsing et al. (2012)
UGT1A	rs6717546			364	394		0.04	12			Gilsing et al. (2012)
UGT1A	rs12466997			364	394		0.08	12			Gilsing et al. (2012)
Arachidonic acid pathway
PTGS2 (COX-2)	rs689566	A-1195G	AA–AG	900	1,686	1.02 (0.98–1.05)		1, 2, 3	Andersen	2013	Andersen et al. (2013b)
			GG	47	61	1.06 (0.87–1.29)	0.54	1, 2, 3			Andersen et al. (2013b)
	rs20417	G-765C	GG	701	1,256	0.99 (0.95–1.03)		1, 2, 3			Andersen et al. (2013b)
			GC–CC	235	478	1.08 (1.01–1.15)	0.006	1, 2, 3			Andersen et al. (2013b)
	rs5275	T8473C	TT	430	720	1.04 (0.99–1.09)		1, 2, 3			Andersen et al. (2013b)
			TC–CC	501	1,018	1.01 (0.96–1.05)	0.29	1, 2, 3			Andersen et al. (2013b)
Transport proteins
ABCB1 (MDR1)	rs1045642	3435	CC	73	118	1.08 (1.00–1.16)		1, 2, 3	Andersen	2009	Andersen et al. (2009)
			CT–TT	286	647	1.00 (0.95–1.06)	0.02	1, 2, 3			Andersen et al. (2009)
	rs3789243	Intron 3	GG	81	224	0.95 (0.89–1.02)		1, 2, 3			Andersen et al. (2009)
			GA–AA	278	541	1.03 (0.98–1.09)	0.01	1, 2, 3			Andersen et al. (2009)
ABCG2 (BCRP)	rs2231142	C421A	CC	296	592	1.02 (0.97–1.08)		1, 2, 3			Andersen et al. (2009)
			CA–AA	63	173	0.99 (0.91–1.08)	0.40	1, 2, 3			Andersen et al. (2009)
ABCC2 (MRP2)	rs717620	C-24T	CC	260	508	1.02 (0.97–1.07)		1, 2, 3	Andersen	2012	Andersen et al. (2012b)
			CT–TT	129	280	1.03 (0.95–1.12)	0.72	1, 2, 3			Andersen et al. (2012b)
	rs2273697	G1249A	GG	238	480	1.05 (0.99–1.11)		1, 2, 3			Andersen et al. (2012b)
			AG–AA	151	308	0.98 (0.91–1.05)	0.10	1, 2, 3			Andersen et al. (2012b)
	rs3740066	C3972T	CC	143	301	1.01 (0.96–1.08)		1, 2, 3			Andersen et al. (2012b)
			CT–TT	246	487	1.03 (0.97–1.10)	0.69	1, 2, 3			Andersen et al. (2012b)
Cytokines
IL10	rs1800872	C-592A	CC	238	470	1.02 (0.97–1.07)		1, 2, 3, 9	Andersen	2012	Andersen et al. (2012b)
			AC–AA	140	305	1.02 (0.95–1.11)	0.92	1, 2, 3, 9			Andersen et al. (2012b)
	rs3024505		CC	268	553	1.02 (0.96–1.08)		1, 2, 3, 9			Andersen et al. (2012b)
			CT–TT	110	222	1.03 (0.96–1.10)	0.78	1, 2, 3, 9			Andersen et al. (2012b)
IL10	rs1800872	C-592A	CC	596	1072	1.02 (0.98–1.06)		1, 2, 3	Andersen	2013	Andersen et al. (2013b)
			AC–AA	353	676	1.00 (0.95–1.06)	0.46	1, 2, 3			Andersen et al. (2013b)
	rs3024505		CC	648	1,200	1.00 (0.96–1.04)		1, 2, 3			Andersen et al. (2013b)
			CT–TT	297	565	1.06 (1.00–1.11)	0.04	1, 2, 3			Andersen et al. (2013b)
IL1B	rs4848306	C-3737T	CC	336	560	1.01 (0.96–1.07)		1, 2, 3			Andersen et al. (2013b)
			CT–TT	605	1,186	1.02 (0.98–1.06)	0.65	1, 2, 3			Andersen et al. (2013b)
	rs1143623	G-1464C	GG	454	925	1.02 (0.97–1.06)		1, 2, 3			Andersen et al. (2013b)
			GC–CC	492	824	1.02 (0.97–1.07)	0.94	1, 2, 3			Andersen et al. (2013b)
	rs1143627	T-31C	TT	389	773	1.00 (0.96–1.05)		1, 2, 3			Andersen et al. (2013b)
			TC–CC	557	983	1.03 (0.98–1.07)	0.40	1, 2, 3			Andersen et al. (2013b)
Transcription factors
NFKB1	rs28362491	−94 ins/del	II	122	307	0.96 (0.90–1.04)		1, 2, 3	Andersen	2010	Andersen et al. (2010)
			ID–DD	261	456	1.03 (0.97–1.08)	0.03	1, 2, 3			Andersen et al. (2010)
NR1I2 (PXR)	rs1523127	A-24381C	AA	131	261	1.04 (0.97–1.12)		1, 2, 3			Andersen et al. (2010)
			AC–CC	252	502	1.01 (0.95–1.06)	0.20	1, 2, 3			Andersen et al. (2010)
	rs2276707	C8055T	CC	237	448	1.02 (0.96–1.08)		1, 2, 3			Andersen et al. (2010)
			CT–TT	146	315	1.01 (0.95–1.08)	0.74	1, 2, 3			Andersen et al. (2010)
	rs6785049	A7635G	AA	137	264	1.01 (0.95–1.07)		1, 2, 3			Andersen et al. (2010)
			AG–GG	246	499	1.02 (0.96–1.08)	0.60	1, 2, 3			Andersen et al. (2010)
NR1H2 (LXR)	rs1405655		CC	40	76	1.01 (0.93–1.10)		1, 2, 3			Andersen et al. (2010)
			CT–TT	343	687	1.02 (0.96–1.07)	0.94	1, 2, 3			Andersen et al. (2010)
	rs2695121		TT	117	227	1.03 (0.96–1.11)		1, 2, 3			Andersen et al. (2010)
			CT–CC	266	536	1.01 (0.96–1.07)	0.43	1, 2, 3			Andersen et al. (2010)
Heme oxygenase											Andersen et al. (2011a)
HMOX1 (HO-1)	rs2071746	A-413T	AA	118	260	1.00 (0.93–1.08)		1, 2, 3	Andersen	2011	Andersen et al. (2011a, b)
			AT–TT	265	503	1.02 (0.97–1.08)	0.55	1, 2, 3			Andersen et al. (2011a, b)
DNA repair
MSH3	rs184967	R940Q	RR	127				8, 10	Berndt	2007	Berndt et al. (2007)
			RQ–QQ	65			0.08	8, 10			Berndt et al. (2007)
MSH3	rs26279	T1036A	TT	85				8, 10			Berndt et al. (2007)
			TA–AA	102			0.002	8, 10			Berndt et al. (2007)
MSH6	rs1042821	G39E	GG	118				8, 10			Berndt et al. (2007)
			GE–EE	54			0.29	8, 10			Berndt et al. (2007)
MLH1	rs1799977	I219V	II	84				8, 10			Berndt et al. (2007)
			IV–VV	101			0.40	8, 10			Berndt et al. (2007)
XPC	Rs2228001^d	Lys939Gln	AA	141	307	1.17 (0.71–1.92)		7, 11	Hansen	2007	Hansen et al. (2007)
			AC	204	392	1.11 (0.70–1.75)		7, 11			Hansen et al. (2007)
			CC	50	98	3.70 (1.70–8.04)	0.01	7, 11			Hansen et al. (2007)
XPA		A23G	GG	176	339	1.30 (0.78–2.17)		7, 11			Hansen et al. (2007)
			AG	187	359	1.41 (0.87–2.26)		7, 11			Hansen et al. (2007)
			AA	31	90	0.76 (0.34–1.66)	0.37	7, 11			Hansen et al. (2007)
ERCC2 (XPD)	Rs1799793^d	Asp312Asn	GG	159	333	1.25 (0.69–2.26)		7, 11			Hansen et al. (2007)
			AG	191	354	1.25 (0.83–1.87)		7, 11			Hansen et al. (2007)
			AA	46	108	1.22 (0.61–2.45)	1.00	7, 11			Hansen et al. (2007)
XPC	Rs2228001^d	Lys939Gln	AA	141	307	0.63 (0.23–1.69)		8, 11			Hansen et al. (2007)
			AC	204	392	0.94 (0.41–2.15)		8, 11			Hansen et al. (2007)
			CC	50	98	3.78 (0.64–22.29)	0.20	8, 11			Hansen et al. (2007)
XPA		A23G	GG	176	339	0.58 (0.23–1.48)		8, 11			Hansen et al. (2007)
			AG	187	359	1.87 (0.73–4.83)		8, 11			Hansen et al. (2007)
			AA	31	90	0.31 (0.06–1.64)	0.06	8, 11			Hansen et al. (2007)
ERCC2 (XPD)	Rs1799793^d	Asp312Asn	GG	159	333	1.07 (0.38–3.03)		8, 11			Hansen et al. (2007)
			AG	191	354	0.75 (0.33–1.68)		8, 11			Hansen et al. (2007)
			AA	46	108	1.93 (0.43–8.63)	0.49	8, 11			Hansen et al. (2007)

^aOdds ratio (OR) or incidence rate ratio (IRR)
^b P for interaction (P _int) between meat and the genotypes in relation to CRC has been retrieved from the studies and may have been calculated in different ways
^cComments: (1) Incidence rate ratio (IRR) for colorectal cancer per intake of 25 g red or processed meat. (2) Adjusted for sex and age, smoking status, alcohol, HRT status (women only), BMI, NSAID use, and dietary fibre. (3) P value for interaction between the genotype and dietary intake for the fully adjusted risk estimate. (4) Tertile analyses of daily red meat intake (≤0.5, >0.5–1, <1). 5) Tertile analyses of intake of beef, pork, or lamb as a main dish (≤0.5, >0.5 servings per day). (6) IRR for colorectal cancer per intake of 25 g red meat. (7) Intake of red meat. (8) Intake of processed meat. (9) These data (Andersen et al. 2012a, b) are also included in (Andersen et al. 2013a, b). (10) Adjusted for age, race, and energy intake. (11) Adjusted for average smoking intensity, intake of alcohol, fruits/vegetable, fish/poultry, red meat, dietary fibres, BMI, and hormone replacement therapy. (12) Interactions between intake of benzo{a]pyrene (B[a]P), 2-amino-3,8-dimethylimidazol[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazol[4,5-f]quinoxaline (DiMeIQx), and combined nitrate and nitrite, respectively, and the polymorphisms
^drs number was not provided by the authors. Rs number has been identified and provided as described in the “Methods” section in cases where the rs number could be unambiguously identified

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