Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

Table 2 Regression analyses carried out with each SNP allele as a predictor and weight maintenance scores as outcome separately for males and females

SNP	Gene	No. of subjects	P value	P _corr	Minor allel	MAF %
Males
rs8031741	ACAN	159	9.57E−26	<0.001	G	0.3
rs2271649	ADAM12	158	5.12E−07	<0.001	A	0.9
rs16859850	CCDC80	158	4.08E−17	<0.001	G	0.6
rs2300792	COL12A1	157	1.43E−22	<0.001	C	0.3
rs16918099	COL15A1	159	3.29E−05	0.005	A	0.2
rs16918124	COL15A1	159	6.19E−05	0.008	C	0.5
rs7863250	COL15A1	159	6.19E−05	0.008	C	0.5
rs2672826	COL23A1	157	4.74E−04	0.048	A	12.1
rs12477499	COL3A1	159	2.49E−14	<0.001	G	0.3
rs12589592	FBLN5	159	2.13E−04	0.023	A	33.1
rs12050562	FBN1	159	8.75E−05	0.010	T	0.8
rs7606877	GPC1	159	1.41E−14	<0.001	A	0.5
rs9492168	LAMA2	158	7.50E−17	<0.001	T	0.3
rs2158836	LAMB1	159	1.75E−04	0.020	A	37.1
rs10911215	LAMC1	159	1.11E−09	<0.001	T	1.3
rs2513812	MATN2	159	4.36E−09	<0.001	G	1.3
rs1151578	NID2	158	2.53E−08	<0.001	T	0.2
rs6480654	P4HA1	157	2.67E−12	<0.001	A	0.2
rs1382192	PDIA4	159	4.90E−13	<0.001	A	0.5
rs4727007	PDIA4	159	4.90E−13	<0.001	G	0.5
rs10197695	PDIA6	159	1.26E−14	<0.001	G	0.3
rs7323378	POSTN	158	1.10E−05	0.002	C	48.0
rs9547947	POSTN	149	2.62E−05	0.004	A	38.3
rs9315503	POSTN	159	2.20E−04	0.023	G	33.9
rs7679471	TLL1	159	3.36E−07	<0.001	C	0.2
Females
rs8031741	ACAN	309	5.14E−16	0.000	G	0.3
rs4871046	COL14A1	307	5.49E−09	0.000	C	0.5
rs16918099	COL15A1	310	5.75E−44	0.000	A	0.2
rs12477499	COL3A1	310	2.19E−43	0.000	G	0.3
rs17516906	FN1	303	1.28E−04	0.040	G	7.4
rs1151578	NID2	310	5.19E−06	0.002	T	0.2
rs11925421	PLOD2	310	7.20E−10	0.000	G	0.6
rs7078493	TLL2	310	5.19E−06	0.000	T	0.2
rs310517	VCAN	310	1.79E−25	0.000	T	0.5

P values are derived from univariate linear regression analyses, and P _corr are P values corrected for false discovery rate. P _corr values <0.05 are considered significant, and SNPs with a MAF < 5 % are excluded. SNPs in bold have P _corr values <0.05 and MAF > 5 %
MAF minor allel frequency

ISSN: 1865-3499