Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

Table 3 Interaction between variants in WNT-associated genes and quintiles of fiber intake on type 2 diabetes incidence

			Genotype			HR^{b, c, d, e}	95 % CI	P ^{b, c, d, e}
	Alleles	Risk allele	XX	XR^a	RR
TCF7L2 rs7903146	C/T	T	13,475	9414	1720	1.20^c	1.05–1.36	0.006
Fiber						0.96^d	0.93–0.998	0.037
TCF7L2 rs7903146 × Fiber						1.04^e	1.003–1.09	0.034
TCF7L2 rs12255372	G/T	T	13,517	9689	1785	1.06	0.93–1.21	0.36
Fiber						0.95	0.91–0.98	0.003
TCF7L2 rs12255372 × Fiber						1.06	1.02–1.10	0.005
HHEX rs1111875	A/G	G	4329	12,518	8816	0.99	0.88–1.11	0.83
Fiber						0.95	0.90–1.00	0.05
HHEX rs1111875 × Fiber						1.03	0.99–1.07	0.14
HNF1A rs7957197	A/T	T	1067	8549	16,401	1.15	0.99–1.34	0.06
Fiber						1.00	0.92–1.08	0.92
HNF1A rs7957197 × Fiber						0.99	0.95–1.04	0.75
NOTCH2 rs10923931	G/T	T	20,612	4372	228	1.24	1.02–1.51	0.035
Fiber						1.00	0.97–1.03	0.97
NOTCH2 rs10923931 × Fiber						0.93	0.87–0.99	0.017
TLE4 rs13292136	C/T	C	186	3928	21,962	0.99	0.81–1.23	0.96
Fiber						0.97	0.86–1.10	0.66
TLE4 rs13292136 × Fiber						1.01	0.94–1.07	0.88
ZBED3 rs4457053	A/G	G	13,455	9362	1642	1.22	1.06–1.39	0.004
Fiber						1.02	0.98–1.05	0.38
ZBED3 rs4457053 × Fiber						0.94	0.90–0.98	0.002
PPARG rs1801282	G/C	C	548	6263	19,038	1.18	0.99–1.40	0.06
Fiber						1.01	0.92–1.12	0.77
PPARG rs1801282 × Fiber						0.98	0.93–1.04	0.52
PPARG rs13081389	A/G	A	165	3256	21,423	0.97	0.77–1.21	0.77
Fiber						0.93	0.81–1.07	0.30
PPARG rs13081389 × Fiber						1.03	0.96–1.10	0.46

HR hazard ratio
^aX designates the non-risk allele and R designates the risk allele
^bAdjusted for age, sex, BMI, total energy intake, dietary assessment method, season, leisure-time physical activity, smoking, alcohol intake, and education
^cMain effect per risk allele from the multivariable model including the interaction term
^dMain effect per quintile of fiber intake from the multivariable model including the interaction term
^eInteraction effect

ISSN: 1865-3499