The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study

Genes & Nutrition

Table 3 Dietary intakes by MTHFR risk and MTHFR non-risk participants who received folate-related goal (i.e. those who were told that they needed to increase their folate intake and those who were told to maintain their current folate intakes) compared with those who received generic healthy eating advice (control group)

	MTHFR risk (CT/TT)	Number	MTHFR non-risk (CC)	Number	Control	Number	p value^a
Energy (kJ) M0	9506 ± 3225	121	9013 ± 2873	57	10,617 ± 4810	309	0.325
M6	8589 ± 3028	121	7859 ± 2199	57	9605 ± 4132	309	0.325
Folate (μg per 10 MJ) M0	402 ± 156	121	330 ± 80	57	410 ± 186	309	0.033
M6	429 ± 198	121	398 ± 172^c	57	410 ± 210ⁿ	309	0.033
Liver (g) M0	1 ± 3	121	2 ± 4	57	1 ± 3	309	0.074
M6	2 ± 4	121	1 ± 4	57	1 ± 3	309	0.074
Poultry (g) M0	34 ± 47	100	27 ± 29	52	30 ± 29	270	0.096
M6	34 ± 34	100	24 ± 25	52	32 ± 52	270	0.096
Shellfish (g) M0	4 ± 7	121	3 ± 6	57	3 ± 5	309	0.167
M6	3 ± 5	121	2 ± 5	57	3 ± 7	309	0.167
Green leafy veg (g) M0	46 ± 43	121	42 ± 43	57	45 ± 42	309	0.208
M6	49 ± 38	121	44 ± 36	57	46 ± 48	309	0.208
Fortified cereals (g) M0	23 ± 37	121	11 ± 15	57	19 ± 27	309	0.304
M6	24 ± 32	121	14 ± 16	57	20 ± 26	308	0.304
Beans and legumes (g) M0	22 ± 35	100	20 ± 24	52	25 ± 44	270	0.443
M6	22 ± 24	100	27 ± 63	52	21 ± 31	269	0.443

Includes participants who received folate as a target nutrient at month 0 and/or month 3 and excludes drop-outs at months 3 and 6
M0 month 0, M6 month 6
^aValues are presented as means ± standard deviations. All analysis was conducted on the log transformed values. General linear models were used to assess the impact of group on month 6 intake with M0 as a covariate and controlling for country where necessary. Superscript letters denote where the differences lie between groups where superscript letter n means significantly different from the MTHFR non-risk group and superscript letter c means significantly different from the control group

ISSN: 1865-3499