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  1. Research

    Metallothioneins 1 and 2, but not 3, are regulated by nutritional status in rat white adipose tissue

    Cumulating evidence underlines the role of adipose tissue metallothionein (MT) in the development of obesity and type 2 diabetes. Fasting/refeeding was shown to affect MT gene expression in the rodent liver. T...

    Sylwia Szrok, Ewa Stelmanska, Jacek Turyn, Aleksandra Bielicka-Gieldon, Tomasz Sledzinski and Julian Swierczynski

    Genes & Nutrition 2016 11:18

    Published on: 23 June 2016

  2. Research Paper

    The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects

    Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utiliz...

    Mari C. W. Myhrstad, Inger Ottestad, Clara-Cecilie Günther, Einar Ryeng, Marit Holden, Astrid Nilsson, Kirsti W. Brønner, Achim Kohler, Grethe I. A. Borge, Kirsten B. Holven and Stine M. Ulven

    Genes & Nutrition 2016 11:16

    Published on: 31 May 2016

  3. Research

    Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations

    Non-celiac wheat sensitivity is an emerging wheat-related syndrome showing peak prevalence in Western populations. Recent studies hypothesize that new gliadin alleles introduced in the human diet by replacemen...

    Marco Sazzini, Sara De Fanti, Anna Cherubini, Andrea Quagliariello, Giuseppe Profiti, Pier Luigi Martelli, Rita Casadio, Chiara Ricci, Massimo Campieri, Alberto Lanzini, Umberto Volta, Giacomo Caio, Claudio Franceschi, Enzo Spisni and Donata Luiselli

    Genes & Nutrition 2016 11:15

    Published on: 23 May 2016

  4. Research

    Liver-specific NG37 overexpression leads to diet-dependent fatty liver disease accompanied by cardiac dysfunction

    Environmental factors are well-known causes of diseases. However, aside from a handful of risk indicators, genes’ encoding susceptibility to chronic illnesses and their associated environmental triggers are la...

    Xin Zhou, MengMeng Xu, Liyang Wang, Yulian Mu, Rui Feng, Zhilong Dong, Yuexin Pan, Xunzhang Chen, Yongfeng Liu, Shangen Zheng, Donald D. Anthony, Jianjie Ma, Williams B. Isaacs and Xuehong Xu

    Genes & Nutrition 2016 11:14

    Published on: 21 May 2016

  5. Research

    Differences in genome-wide gene expression response in peripheral blood mononuclear cells between young and old men upon caloric restriction

    Caloric restriction (CR) is considered to increase lifespan and to prevent various age-related diseases in different nonhuman organisms. Only a limited number of CR studies have been performed on humans, and r...

    I. P. G. Van Bussel, A. Jolink-Stoppelenburg, C. P. G. M. De Groot, M. R. Müller and L. A. Afman

    Genes & Nutrition 2016 11:13

    Published on: 6 May 2016

  6. Review

    Biomarkers for nutrient intake with focus on alternative sampling techniques

    Biomarkers of nutrient intake or nutrient status are important objective measures of foods/nutrients as one of the most important environmental factors people are exposed to. It is very difficult to obtain acc...

    T. Holen, F. Norheim, T. E. Gundersen, P. Mitry, J. Linseisen, P. O. Iversen and C. A. Drevon

    Genes & Nutrition 2016 11:12

    Published on: 16 April 2016

  7. Research

    Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study

    MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic ...

    Giuseppe Iacomino, Paola Russo, Ilaria Stillitano, Fabio Lauria, Pasquale Marena, Wolfgang Ahrens, Pasquale De Luca and Alfonso Siani

    Genes & Nutrition 2016 11:7

    Published on: 21 March 2016

  8. Research

    Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

    TCF7L2 is a central transcription factor in the canonical wingless-type MMTV integration site (WNT) signaling pathway, and genetic variants in TCF7L2 have been found to interact with dietary fiber intake on type ...

    George Hindy, Inês G. Mollet, Gull Rukh, Ulrika Ericson and Marju Orho-Melander

    Genes & Nutrition 2016 11:6

    Published on: 21 March 2016

  9. Research

    Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels

    Considering that vitamin A deficiency modulates hepcidin expression and consequently affects iron metabolism, we evaluated the effect of vitamin A deficiency in the expression of genes involved in the hemojuve...

    Juliana Frossard Ribeiro Mendes, Egle Machado de Almeida Siqueira, João Gabriel Marques de Brito e Silva and Sandra Fernandes Arruda

    Genes & Nutrition 2016 11:1

    Published on: 17 March 2016

  10. Research Paper

    Comparative anti-inflammatory and lipid-normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats

    Emerging evidence suggests beneficial effects of omega-3 fatty acids on diabetic complications. The present study compared the progressive effects of metformin and flax/fish oil on lipid metabolism, inflammato...

    Abhijit Ghadge, Abhay Harsulkar, Manjiri Karandikar, Vijaya Pandit and Aniket Kuvalekar

    Genes & Nutrition 2016 11:10

    Published on: 17 March 2016

  11. Research Paper

    Effect of a diet enriched with omega-6 and omega-3 fatty acids on the pig liver transcriptome

    The optimal ratio of omega-6 to omega-3 polyunsaturated fatty acids (PUFAs) is important for keeping the homeostasis of biological processes and metabolism, yet the underlying biological mechanism is poorly un...

    Agnieszka Szostak, Magdalena Ogłuszka, Marinus F. W. te Pas, Ewa Poławska, Paweł Urbański, Edyta Juszczuk-Kubiak, Tadeusz Blicharski, Chandra Shekhar Pareek, Jenelle R. Dunkelberger, Jarosław O. Horbańczuk and Mariusz Pierzchała

    Genes & Nutrition 2016 11:9

    Published on: 17 March 2016

  12. Research

    Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study

    Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term healthy Nordic diet...

    Lena Leder, Marjukka Kolehmainen, Ingunn Narverud, Ingrid Dahlman, Mari C. W. Myhrstad, Vanessa D. de Mello, Jussi Paananen, Carsten Carlberg, Ursula Schwab, Karl-Heinz Herzig, Lieselotte Cloetens, Matilda Ulmius Storm, Janne Hukkanen, Markku J. Savolainen, Fredrik Rosqvist, Kjeld Hermansen…

    Genes & Nutrition 2016 11:3

    Published on: 17 March 2016

  13. Research Paper

    Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

    The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of...

    Nadia J. T. Roumans, Roel G. Vink, Marij Gielen, Maurice P. Zeegers, Claus Holst, Ping Wang, Arne Astrup, Wim H. Saris, Armand Valsesia, Jörg Hager, Marleen A. van Baak and Edwin C. M. Mariman

    Genes & Nutrition 2015 10:56

    Published on: 19 November 2015

  14. Research Paper

    Consumer adoption of personalised nutrition services from the perspective of a risk–benefit trade-off

    Through a Privacy Calculus (i.e. risk–benefit trade-off) lens, this study identifies factors that contribute to consumers’ adoption of personalised nutrition services. We argue that consumers’ intention to ado...

    Aleksandra Berezowska, Arnout R. H. Fischer, Amber Ronteltap, Ivo A. van der Lans and Hans C. M. van Trijp

    Genes & Nutrition 2015 10:42

    Published on: 25 September 2015

  15. Research Paper

    Nutritional systems biology of type 2 diabetes

    Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been ...

    Yuqi Zhao, Rio Elizabeth Barrere-Cain and Xia Yang

    Genes & Nutrition 2015 10:31

    Published on: 24 July 2015

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