Fig. 1
From: Epigenetic changes induced by curcumin and other natural compounds
a The fundamental repeating unit of the chromatin is the nucleosome. A single nucleosomal core is composed of a DNA fragment wrapped around a histone octamer, formed by an H3-H4 tetramer and two H2A-H2B dimers. Each successive nucleosomal core is separated by a DNA linker associated with a single molecule of histone H1. b Chromatin modifications usually occur at the amino acids of the N-terminal tails of histones. These histone tails are the site for a wide range of post-translational modifications, including acetylation controlled by histone acetyltransferases (HATs), deacetylation controlled by histone deacetylases (HDACs), and methylation controlled by DNA methyltransferases (DNMTs)