TY - JOUR AU - Youn, Yu Na AU - Lim, Erang AU - Lee, Nari AU - Kim, Young Seop AU - Koo, Min Seon AU - Choi, Soon Young PY - 2008 DA - 2008/02/01 TI - Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro JO - Genes & Nutrition SP - 375 EP - 380 VL - 2 IS - 4 AB - Bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. Bone resorption and loss are generally attributed to osteoclasts. Differentiation of osteoclasts is regulated by receptor activator of nuclear factor NF-kB ligand (RANKL), a member of tumor necrosis factor family. When the balance is disturbed, pathological bone abnormality ensues. Through the screening of traditional Korean medicinal plants, the effective molecules for inhibition and stimulation of RANKL-induced osteoclast differentiation in mouse bone marrow macrophages were identified. Among 222 methanol extracts, of medicinal plants, 10 samples exhibited ability to induce osteoclast differentiation. These include Dryobalanops aromatica, Euphoria longana, Lithospermum erythrorhizon, Prunus mume, Prunus nakaii, and Polygonatum odoratum. In contrast, Ailanthus altissima, Curcuma longa, Solanum nigrum, Taraxacum platycarpa, Trichosanthes kirilowii, and Daphne genkwa showed inhibitory effects in RANKL-induced osteoclast differentiation. SN - 1865-3499 UR - https://doi.org/10.1007/s12263-007-0062-1 DO - 10.1007/s12263-007-0062-1 ID - Youn2008 ER -