Table 1 Classified target genes implicated in cytoprotective effects of SFE on Dox-induced toxicity
Accession no. | Description | Expression patterna |
|---|---|---|
Glutathione metabolism and detoxification | ||
NM_053293 | Glutathione S-transferase theta 1 | up–up |
M28241 | Glutathione S-transferase, mu 1 | nc–up |
NM_017013 | Glutathione S-transferase, alpha type2 | up–up |
NM_053840 | Gamma-glutamyltransferase 1 | up–up |
NM_012580 | Heme oxygenase (decycling) 1 | up–up |
NM_012844 | Epoxide hydrolase 1, microsomal | nc–up |
Lipid metabolism | ||
BM390364 | Transmembrane 7 superfamily member 2 | nc–up |
NM_031559 | Carnitine palmitoyltransferase 1, liver | up–up |
U66322 | Leukotriene B4 12-hydroxydehydrogenase | up–up |
BI276935 | Dehydrogenase/reductase (SDR family) member 3 | nc–up |
BI293393 | Crystallin, lamda 1 | nc–up |
NM_133586 | Carboxylesterase 2 (intestine, liver) | up–up |
NM_012715 | Adrenomedullin | up–up |
AA996933 | CGI-58-like protein | up–up |
Carbohydrate metabolism | ||
NM_031510 | Isocitrate dehydrogenase 1 (NADP+), soluble | nc–up |
NM_134407 | Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | nc-up |
NM_031972 | Aldehyde dehydrogenase family 3, member A1 | up–up |
NM_031811 | Transaldolase 1 | up–up |
NM_022592 | Transketolase | up–up |
Protein, amino acid metabolism | ||
J02827 | Branched chain ketoacid dehydrogenase E1, alpha polypeptide | nc–up |
AI169359 | Cathepsin F | up–up |
Transmembrane and transport | ||
NM_021654 | gap junction membrane channel protein alpha 4 | nc–up |
AB043636 | Potassium inwardly-rectifying channel, subfamily J, member 8 | nc–up |
BI285135 | Similar to DNA segment, Chr 11, ERTO Doi 18, expressed | nc–up |
AI235230 | Potassium channel tetramerisation domain containing 13 | up–up |
AW915385 | Golgi associated, gamma adaptin ear containing, ARF binding protein 2 | nc–up |
NM_133315 | Solute carrier family 39 (iron-regulated transporter), member 1 | up–up |
BM386498 | Vacuolar protein sorting 33a (yeast) | nc–up |
NM_017154 | Xanthine dehydrogenase | nc–up |
Immune response | ||
AA866388 | Cytokine receptor-like factor 1 (predicted) | up–up |
AF253065 | Chemokine-like factor 1 | nc–up |
AA925583 | B-cell linker | nc–up |
AI176519 | Immediate early response 3 | nc–up |
NM_030854 | Leukocyte cell derived chemotaxin 1 | nc–up |
AI070686 | Integrin, beta 6 | down–up |
Electron transport, energy metabolism | ||
AI170570 | Coenzyme Q6 homolog (yeast) | up–up |
AI179227 | Similar to hypothetical protein MGC20446 | nc–up |
AI501131 | Lactate dehydrogenase D | nc–up |
Chromosomal protein | ||
NM_022686 | Germinal histone H4 gene | up–up |
AI235236 | Histone 2, Hh2aa (predicted) | up–up |
Apoptosis | ||
U24174 | Cyclin-dependent kinase inhibitor 1A | nc–up |
AA818262 | Angiopoietin-like protein 4 | up–up |
Cell migration, cell motility, localization of cell | ||
AI146115 | EPH receptor B1 | nc–up |
NM_053843 | Fc receptor, Igg, low affinity III | up–up |
AI112954 | ABI gene family, member 3 | nc–up |
Signal transduction | ||
AB004454 | Presenilin 2 | up–up |
NM_012580 | Heme oxygenase (decycling) 1 | up–up |
Transcription | ||
BF403357 | hpaII tiny fragments locus 9C | nc–up |
Others | ||
AY081218 | Pregnancy-induced growth inhibitor | up–up |
BF403568 | UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (predicted) | up–up |
AI059015 | Ectonucleoside triphosphate diphosphohydrolase 5 | up–up |
BI278288 | Similar to RIKEN cDNA 0610039C21 (predicted) | up–up |
AI235236 | Similar to Hist2h2aa1 protein | up–up |
BF416240 | Hypothetical LOC300751 (predicted) | nc–up |
BG375890 | Similar to hypothetical protein | nc–up |
BI295064 | Similar to brain protein 17 | nc–up |
AI411088 | Similar to RIKEN cDNA 4930570c03 | up–up |
⊥BI296172 | Similar to 2310010G13Rik protein | up–up |
AI012782 | Similar to cell surface receptor FDFACT, similar to paired immunoglobin-like type 2 receptor beta | nc–up |
BI294552 | Similar to RIKEN cDNA 2310011J03 | up–up |
AI171553 | Similar to RIKEN cDNA 6330406I15 (predicted) | down–up |
AI548652 | Similar to hypothetical 55.1 kDa protein F09G8.5 in chromosome III | nc–up |