Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures

Table 3 Summary of genome-wide responses of lungs to diets in air and cigarette smoke (CS) exposed mice

Diet/treatment	Total number of genes affected	% of total number of genes affected	Up-regulated	Down-regulated
BC/AIR	13	0.09	11	2
LY/AIR	3	0.02	1	2
Basal/CS	40	0.27	27	13
BC/CS	73	0.49	17	56
LY/CS	65	0.43	54	11

Effects of dietary β-carotene (BC) or lycopene (LY) on gene expression in the lungs of air breathing mice were obtained by comparing the entire list of genes from mice fed either BC- or LY-supplemented diet with that obtained from the lungs of air breathing mice fed the basal diet. The number differentially expressed, carotenoid sensitive genes (column 2) is also shown as the % of the total number of genes detected in the lungs from either BC- or LY-fed mice (column 3). CS sensitive genes in each dietary group were obtained by comparing the entire list of genes detected in the lungs of CS breathing mice with that expressed in air breathing mice. The total number of differentially expressed, CS sensitive genes (column 2) is shown also shown as % of the total genes detected (column 3) in the lungs of CS breathing mice

ISSN: 1865-3499