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Table 5 Differential expression of genes modulated by carotenoids and cigarette smoke

From: Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures

Gene name and description

Signal intensity

Accession no.

CA

CCS

BA

BCS

LYA

LYCS

Xenobiotic/drug metabolism

Cytochrome P450, 1a1; Cyp1a1

81 ± 16

4,947 ± 730***

126 ± 15

3,985 ± 168***

157 ± 7

4,652 ± 326***

NM_009992

Cytochrome P450, f1b1; Cyp1b1

223 ± 61

2,150 ± 541**

113 ± 7

1,657 ± 110***

165 ± 15

1,760 ± 1023***

BI251808

Cytochrome P450, family 2, a4///a5; Cyp2a4///Cyp2a5

938 ± 336

2,042 ± 477**

942 ± 69

2,071 ± 127***

630 ± 113

2,195 ± 273**

NM_007812

Aldehyde dehydrogenase family 3, a1; Aldh3a1

378 ± 91

1,072 ± 262**

171 ± 12

836 ± 43***

312 ± 24

1,296 ± 61***

NM_007436

Alcohol dehydrogenase 7 (class IV); Adh7

269 ± 73

814 ± 182**

151 ± 13

718 ± 33***

201 ± 18

859 ± 109**

NM_009626

Aldo-keto reductase family 1, member B8; Akr1b8

623 ± 175

945 ± 242#

343 ± 30

759 ± 36***

449 ± 3

1,095 ± 70***

NM_008012

Carboxylesterase 1; Ces1

93 ± 29

511 ± 146**

68 ± 8

420 ± 35***

88 ± 7

575 ± 42***

NM_021456

NAD(P)H dehydrogenase, quinone 1; Nqo1

119 ± 23

403 ± 64**

85 ± 3

366 ± 8***

124 ± 8

534 ± 10***

AV158882

Glutathione S-transferase, alpha 2; Gsta2

242 ± 60

569 ± 159#

148 ± 13

485 ± 11***

245 ± 19

654 ± 39***

NM_008182

Glutathione S-transferase, alpha 3; Gsta3

349 ± 91

770 ± 139

294 ± 21

615 ± 58**

364 ± 16

771 ± 42***

AI172943

Carbonyl reductase 3; Cbr3

604 ± 148

1,398 ± 304*

284 ± 87

1,174 ± 29***

469 ± 23

1,472 ± 67***

AK003232

Glutathione reductase 1; Gsr

277 ± 30

348 ± 29#

492 ± 48

443 ± 18#

356 ± 15

1,007 ± 176**

AK019177

Glutamate-cysteine ligase, modifier subunit; Gclm

402 ± 75

887 ± 173**

320 ± 14

706 ± 32***

326 ± 35

1,105 ± 29***

NM_008129

Flavin containing monooxygenase 2; Fmo2

1,814 ± 583

2,284 ± 629#

1,203 ± 188

1,688 ± 156#

876 ± 115

2,056 ± 127***

NM_018881

Inflammatory-immune response

Paired-Ig-like receptor A1; Pira1

138 ± 38

80 ± 29#

139 ± 20

69 ± 4**

108 ± 5

310 ± 64**

NM_011087

Paired immunoglobin-like type 2 receptor alpha; Pilra

139 ± 42

104 ± 48#

130 ± 10

73 ± 7**

89 ± 2

262 ± 62*

BB775785

Paired immunoglobin-like type 2 receptor beta; Pilrb

248 ± 47

166 ± 46#

254 ± 34

92 ± 3**

186 ± 10

563 ± 131*

NM_133209

EGF-like module containing, mucin-like, r4; Emr4

285 ± 99

170 ± 117#

179 ± 13

45 ± 3***

191 ± 15

162 ± 22#

AF396935

Killer cell lectin-like receptor, a3; Klra3

595 ± 188

307 ± 103#

299 ± 21

131 ± 16***

401 ± 42

365 ± 48#

U49865

Fibrinogen-like protein 2; Fgl2

269 ± 90

165 ± 58#

240 ± 43

120 ± 9**

171 ± 10

377 ± 63**

BF136544

Protein tyrosine phosphatase, receptor type, C; Ptprc

3,348 ± 987

1,540 ± 533#

2,266 ± 156

960 ± 50***

2,287 ± 53

3,103 ± 391#

NM_011210

Lymphocyte antigen 86; Ly86

825 ± 272

304 ± 86#

433 ± 45

186 ± 14**

599 ± 70

443 ± 9**

NM_010745

Leukocyte specific transcript 1; Lst1

359 ± 101

127 ± 46*

280 ± 54

49 ± 6**

215 ± 20

460 ± 84*

U72644

Coronin, actin binding protein 1A; Coro1a

1,153 ± 319

574 ± 180#

821 ± 91

416 ± 37**

910 ± 113

1,415 ± 231#

BB740218

GLI pathogenesis-related 2; Glipr2

146 ± 44

65 ± 24#

148 ± 15

62 ± 2**

132 ± 3

276 ± 68#

BM208214

Matrix metalloproteinase 8; Mmp8

145 ± 33

86 ± 11#

272 ± 83

78 ± 11**

69 ± 6

2,465 ± 670**

NM_008611

Matrix metalloproteinase 9; Mmp9

185 ± 33

84 ± 18**

222 ± 66

68 ± 5**

92 ± 3

830 ± 237**

NM_013599

Interleukin 1 beta; Il1b

534 ± 171

141 ± 39*

763 ± 243

102 ± 12**

179 ± 37

1,759 ± 464**

BC011437

Interleukin 8 receptor, beta; Il8rb

83 ± 29

19 ± 5*

103 ± 37

14 ± 7**

20 ± 6

256 ± 41**

NM_009909

Phospholipase A2, group VII; Pla2g7

229 ± 66

129 ± 55#

350 ± 77

129 ± 8**

124 ± 14

975 ± 244**

AK005158

Colony stimulating factor 3 receptor (granulocyte); Csf3r

417 ± 90

163 ± 45**

619 ± 200

133 ± 23**

175 ± 30

1,322 ± 279**

NM_007782

Formyl peptide receptor, related sequence 2; Fpr-rs2

475 ± 110

399 ± 165#

383 ± 44

217 ± 7**

273 ± 14

1,256 ± 282**

NM_008039

Formyl peptide receptor 1; Fpr1

238 ± 63

154 ± 41#

224 ± 11

126 ± 15**

133 ± 19

572 ± 140**

NM_013521

Secretory leukocyte protease inhibitor; Slpi

721 ± 115

683 ± 193#

735 ± 96

655 ± 89#

461 ± 44

1,817 ± 331**

NM_011414

Synuclein, alpha; Snca

393 ± 87

601 ± 109#

292 ± 17

388 ± 31**

398 ± 25

954 ± 109**

NM_009221

Fc receptor, IgG, low affinity III; Fcgr3

287 ± 57

278 ± 65#

300 ± 35

201 ± 26*

213 ± 21

730 ± 129**

NM_010188

Triggering receptor expressed on myeloid cells 3; Trem3

131 ± 32

89 ± 31#

108 ± 8

41 ± 2***

76 ± 4

315 ± 64**

NM_021407

Cadherin 2; Cdh2

154 ± 39

101 ± 35#

128 ± 15

95 ± 8#

223 ± 12

166 ± 16**

BC022107

Glycoprotein 49 A; Gp49a///Lilrb4

945 ± 247

580 ± 157#

945 ± 193

413 ± 15**

580 ± 12

1,564 ± 263**

U05264

C-type lectin domain family 4, member d; Clec4d

214 ± 42

121 ± 38#

413 ± 128

103 ± 12**

122 ± 12

1,226 ± 341**

NM_010819

C-type lectin domain family 4, member e; Clec4e

59 ± 19

44 ± 19#

63 ± 18

22 ± 2*

26 ± 4

226 ± 72*

NM_019948

Metabolism and ion-channels

Argininosuccinate synthetase 1; Ass1

183 ± 42

253 ± 50#

209 ± 78

174 ± 10#

145 ± 8

186 ± 23#

NM_007494

Histidine decarboxylase; Hdc

1,075 ± 269

368 ± 127*

624 ± 48

304 ± 14***

844 ± 97

862 ± 139#

BG072171

Ubiquitin specific protease 2; Usp2

111 ± 33

214 ± 57#

64 ± 2

162 ± 8***

95 ± 6

153 ± 7**

AI553394

Lysyl oxidase-like 1; Loxl1

1,666 ± 319

642 ± 181**

1,000 ± 74

454 ± 48***

1573 ± 55

874 ± 141**

AF357006

Sodium channel, voltage-gated, 3b; Scn3b

1,220 ± 201

681 ± 170#

753 ± 55

348 ± 28***

1,221 ± 139

910 ± 136#

BE951842

Stearoyl-Coenzyme A desaturase 1; Scd1

917 ± 265

617 ± 124#

801 ± 82

341 ± 59**

1,192 ± 292

937 ± 195#

NM_009127

Serine (or cysteine) proteinase inhibitor, clade H1; Serpinh1

1,377 ± 40

802 ± 74***

1,574 ± 153

799 ± 76**

1,915 ± 230

1,253 ± 188*

BB329489

Solute carrier family 7a10; Slc7a10

415 ± 46

270 ± 42*

381 ± 12

214 ± 18***

533 ± 35

414 ± 57#

NM_017394

Solute carrier family 28a2; Slc28a2

146 ± 41

51 ± 13*

128 ± 21

37 ± 6**

125 ± 19

274 ± 66#

NM_021520

Topoisomerase (DNA) II alpha; Top2a

183 ± 43

117 ± 30#

127 ± 8

74 ± 8**

62 ± 32

165 ± 20#

BM211413

Solute carrier family 40 (iron-regulated transporter)1; Slc40a1

387 ± 103

310 ± 77#

334 ± 88

284 ± 28#

284 ± 16

1,006 ± 147**

AF226613

Solute carrier family 38, member 5; Slc38a5

462 ± 85

231 ± 55**

285 ± 27

211 ± 26#

472 ± 9

298 ± 44**

BG066984

Guanine deaminase; Gda

92 ± 22

73 ± 23#

105 ± 19

52 ± 4**

61 ± 5

308 ± 65**

NM_010266

Peptidyl arginine deiminase, type IV; Padi4

43 ± 10

20 ± 4#

64 ± 15

17 ± 3**

40 ± 4

249 ± 78*

NM_011061

Arachidonate 5-lipoxygenase activating protein; Alox5ap

1,428 ± 246

1,050 ± 171#

1,226 ± 185

867 ± 27#

1,212 ± 75

2,748 ± 434**

BC026209

Amiloride binding protein 1; Abp1

355 ± 100

116 ± 43*

155 ± 24

106 ± 8#

230 ± 35

94 ± 17**

BC021880

Apoptosis

Granzyme A; Gzma

1,176 ± 392

531 ± 194#

633 ± 44

219 ± 20***

688 ± 92

801 ± 85#

NM_010370

Insulin-like growth factor binding protein 3; Igfbp3

757 ± 122

350 ± 95**

468 ± 38

357 ± 21**

794 ± 23

345 ± 37***

AV175389

Chloride channel calcium activated 1; Clca1

122 ± 24

147 ± 39#

127 ± 22

181 ± 9*

103 ± 4

261 ± 44**

AF047838

Receptor

Angiotensin receptor-like 1; Agtrl1

251 ± 36

138 ± 17**

169 ± 13

135 ± 19#

2,934 ± 210

1,485 ± 453**

BB533323

Membrane-spanning 4-domains, a1; Ms4a1

259 ± 86

95 ± 31#

120 ± 16

55 ± 5**

201 ± 17

159 ± 30#

BB236617

Membrane-spanning 4-domains, a4b; Ms4a4b

655 ± 197

312 ± 126#

342 ± 35

145 ± 11**

481 ± 44

422 ± 62#

BB199001

Membrane-spanning 4-domains, a4c; Ms4a4c

408 ± 145

78 ± 33*

216 ± 51

38 ± 2**

236 ± 47

295 ± 62#

NM_029499

Membrane-spanning 4-domains, a6b; Ms4a6b

1,031 ± 305

549 ± 162#

703 ± 56

332 ± 24***

701 ± 43

805 ± 98#

NM_027209

Cell proliferation

tetraspanin 4; Tspan4

376 ± 64

1,387 ± 243**

532 ± 32

1,145 ± 99***

622 ± 13

1,180 ± 160**

NM_053082

Placenta-specific 8; Plac8

2,254 ± 538

913 ± 292*

1,601 ± 144

485 ± 41***

1,415 ± 114

2,077 ± 200**

AF263458

Unknown function

Macrophage activation 2 like; Mpa2 l

154 ± 33

68 ± 20*

82 ± 10

41 ± 3**

130 ± 10

117 ± 15#

BM241485

Histone 1, H2ad; Hist1h2ad

319 ± 111

230 ± 93#

231 ± 45

132 ± 7*

112 ± 17

351 ± 30**

W91024

Apoptosis

Granzyme A; Gzma

1,176 ± 392

531 ± 194#

633 ± 44

219 ± 20***

688 ± 92

801 ± 85#

NM_010370

Insulin-like growth factor binding protein 3; Igfbp3

757 ± 122

350 ± 95**

468 ± 38

357 ± 21**

794 ± 23

345 ± 37***

AV175389

Chloride channel calcium activated 1; Clca1

122 ± 24

147 ± 39#

127 ± 22

181 ± 9*

103 ± 4

261 ± 44**

AF047838

Receptor

Angiotensin receptor-like 1; Agtrl1

251 ± 36

138 ± 17**

169 ± 13

135 ± 19#

2,934 ± 210

1,485 ± 453**

BB533323

Membrane-spanning 4-domains, a1; Ms4a1

259 ± 86

95 ± 31#

120 ± 16

55 ± 5**

201 ± 17

159 ± 30#

BB236617

Membrane-spanning 4-domains, a4b; Ms4a4b

655 ± 197

312 ± 126#

342 ± 35

145 ± 11**

481 ± 44

422 ± 62#

BB199001

Membrane-spanning 4-domains, a4c; Ms4a4c

408 ± 145

78 ± 33*

216 ± 51

38 ± 2**

236 ± 47

295 ± 62#

NM_029499

Membrane-spanning 4-domains, a6b; Ms4a6b

1,031 ± 305

549 ± 162#

703 ± 56

332 ± 24***

701 ± 43

805 ± 98#

NM_027209

Cell proliferation

Tetraspanin 4; Tspan4

376 ± 64

1,387 ± 243**

532 ± 32

1,145 ± 99***

622 ± 13

1,180 ± 160**

NM_053082

Placenta-specific 8; Plac8

2,254 ± 538

913 ± 292*

1,601 ± 144

485 ± 41***

1,415 ± 114

2,077 ± 200**

AF263458

Unknown function

Macrophage activation 2 like; Mpa2 l

154 ± 33

68 ± 20*

82 ± 10

41 ± 3**

130 ± 10

117 ± 15#

BM241485

Histone 1, H2ad; Hist1h2ad

319 ± 111

230 ± 93#

231 ± 45

132 ± 7*

112 ± 17

351 ± 30**

W91024

Transcription and growth factors

Period homolog 2 (Drosophila); Per2

175 ± 51

983 ± 221**

296 ± 16

857 ± 48***

313 ± 17

926 ± 53***

AF035830

Period homolog 3 (Drosophila); Per3

75 ± 42

384 ± 51**

224 ± 22

438 ± 24***

282 ± 11

409 ± 26

NM_011067

D site albumin promoter binding protein; Dbp

222 ± 63

613 ± 110**

505 ± 58

530 ± 80#

509 ± 44

446 ± 91

BC018323

Cryptochrome 1; Cry1

143 ± 45

260 ± 91#

61 ± 8

222 ± 25***

88 ± 6

281 ± 42**

BG069864

Hepatic leukemia factor; Hlf

150 ± 52

425 ± 129#

173 ± 25

383 ± 25***

188 ± 14

405 ± 76

BB744589

DNA-damage-inducible transcript 4; Ddit4

983 ± 346

1,470 ± 434#

637 ± 110

1,136 ± 122**

967 ± 60

815 ± 92

AK017926

Thyrotroph embryonic factor; Tef

1,545 ± 282

3,447 ± 565**

1,883 ± 124

3,151 ± 182***

2,138 ± 81

2,836 ± 233

BC017689

v-maf musculoaponeurotic fibrosarcoma oncogene family F; Maff

164 ± 31

453 ± 61**

239 ± 35

421 ± 18***

214 ± 18

359 ± 29

BC022952

FK506 binding protein 5; Fkbp5

136 ± 23

377 ± 78**

169 ± 6

397 ± 26***

116 ± 19

327 ± 45**

U16959

Cold inducible RNA binding protein; Cirbp

373 ± 68

502 ± 55#

231 ± 35

551 ± 44***

629 ± 29

610 ± 113#

NM_007705

Epithelial stromal interaction 1 (breast); Epsti1

421 ± 83

274 ± 75#

299 ± 15

149 ± 3***

424 ± 56

399 ± 18#

BF020640

SAM domain, SH3 domain & nuclear localisation signals 1; Samsn1

185 ± 56

104 ± 39#

119 ± 4

53 ± 2***

106 ± 6

197 ± 45#

NM_023380

Neutrophil cytosolic factor 4; Ncf4

226 ± 54

125 ± 44#

190 ± 30

77 ± 4**

168 ± 14

362 ± 66*

NM_008677

Tripartite motif protein 30///tripartite motif protein 30-like; Trim30

646 ± 216

942 ± 598#

398 ± 51

206 ± 22**

376 ± 38

593 ± 64**

BG068242

Nuclear factor, erythroid derived 2; Nfe2

106 ± 18

71 ± 13#

133 ± 14

78 ± 4**

108 ± 5

325 ± 79*

L09600

POU domain, class 2, associating factor 1; Pou2af1

418 ± 10

201 ± 97#

222 ± 38

112 ± 9**

346 ± 21

266 ± 71#

NM_011136

Deafness, autosomal dominant 5 homolog (human); Dfna5 h

47 ± 16

31 ± 6#

43 ± 7

19 ± 4**

28 ± 4

172 ± 45**

NM_018769

Zinc finger and BTB domain containing 16; Zbtb16

101 ± 24

152 ± 33#

113 ± 20

129 ± 14#

74 ± 1

162 ± 21**

Z47205

Erythroid differentiation regulator 1; Erdr1

712 ± 133

642 ± 121#

525 ± 60

442 ± 157#

366 ± 131

870 ± 107**

AJ007909

Nuclear receptor subfamily 1, d1; Nr1d1

415 ± 106

245 ± 29#

406 ± 20

317 ± 33*

504 ± 20

243 ± 40**

W13191

Neuronatin; Nnat

205 ± 57

138 ± 13#

132 ± 12

109 ± 7#

198 ± 24

159 ± 16#

AV218841

Pleckstrin homology domain containing, a6; Plekha6

109 ± 21

98 ± 28#

91 ± 10

72 ± 8#

180 ± 9

99 ± 12**

BB486127

Unknown gene

RIKEN cDNA 9030611N15 gene

1,085 ± 293

2,188 ± 530#

7,12.3 ± 90.3

2,028 ± 102***

788 ± 44

1,899 ± 155***

NM_134072

Expressed sequence AI447904

885 ± 283

364 ± 137#

421 ± 23.7

171 ± 13***

585 ± 53

515 ± 42#

BM241008

DNA segment, Chr 7, Wayne State University 130, expressed

42.2 ± 12.6

124 ± 45#

37 ± 10

95 ± 17**

40 ± 4

94 ± 9**

AI480533

–

289 ± 104

591 ± 176#

252 ± 44

437 ± 59**

364 ± 45

359 ± 56#

BC003855

–

89 ± 37

162 ± 46#

74 ± 13

113 ± 12*

93 ± 25

118 ± 33#

M11024

RIKEN cDNA 1700012B18 gene

138 ± 37

329 ± 81*

112 ± 8

259 ± 18***

145 ± 24

374 ± 37**

BC022135

RIKEN cDNA C130076O07 gene

231 ± 48

81 ± 16**

184 ± 12

70 ± 6***

191 ± 18

97 ± 20**

BB202655

RIKEN cDNA 6330500D04 gene

482 ± 140

239 ± 68#

328 ± 47

149 ± 4**

371 ± 34

610 ± 102#

BM242294

–

518 ± 133

202 ± 48**

228 ± 34

121 ± 8**

368 ± 58

309 ± 27#

BE686052

RIKEN cDNA 1100001G20 gene

208 ± 30

202 ± 50#

311 ± 42

168 ± 16**

153 ± 15

1,268 ± 394*

AV006463

RIKEN cDNA 2300003P22 gene

61 ± 13

33 ± 7#

139 ± 51

96 ± 60#

33 ± 12

842 ± 278*

AK004007

CD300 antigen like family member F

328 ± 93

186 ± 41#

290 ± 78

162 ± 7#

171 ± 7

699 ± 156**

BM230330

  1. Gene symbols are shown in bold figures
  2. *** P < 0.001, ** P < 0.05, # P < 0.5
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Genes & Nutrition

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