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Table 1 Summary of selected genes that are modulated by treatment of LT97 human colon adenoma cells with 50 μM EPA (n = 3) or DHA (n = 2)

From: Modulation of gene expression in eicosapentaenoic acid and docosahexaenoic acid treated human colon adenoma cells

Accession

Gene name

Gene symbol

FC

SD

p value (t test)

EPA 10 h

 NM_001228

Caspase 8

CASP8

0.10

0.17

0.17

 NM_001074

UDP glucuronosyltransferase 2 family, polypeptide B7, 8, 10, 11

UGT2B7_8_10_11

0.23

0.39

0.39

 NM_000410

Hemochromatosis

HFE_3

0.25

0.43

0.37

 NM_000578

Solute carrier family 11, member 1

SLC11A1

0.29

0.50

0.92

 NM_030753

Wingless-type MMTV integration site family, member 3

WNT3

0.30

0.53

0.95

 NM_022467

Carbohydrate sulfotransferase 8

CHST8

2.02

2.66

0.54

 NM_000854

Glutathione S-transferase theta 2

GSTT2

4.04

3.71

0.31

EPA 24 h

 NM_000463

UDP glucuronosyltransferase 1 family, polypeptide A1

UGT1A1

2.00

1.06

0.29

 NM_004985

v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog

KRAS2A-B

2.02

0.31

0.26

 NM_002502

Nuclear factor of kappa light polypeptide gene enhancer in B cells 2

NFKB2

2.12

0.92

0.41

 NM_003998

Nuclear factor of kappa light polypeptide gene enhancer in B cells 1

NFKB1

2.16

1.08

0.19

 NM_000854

Glutathione S-transferase theta 2

GSTT2

2.41

1.65

0.46

 NM_000178

Glutathione synthetase

GSS

2.54

2.31

0.30

 NM_001461

Flavin containing monooxygenase 5

FMO5

2.58

0.54

0.15

DHA 10 h

 NM_001228

Caspase 8

CASP8

0.15

0.21

0.80

 NM_000617

Solute carrier family 11, member 2

SLC11A2_2

0.27

0.16

0.30

 NM_000410

Haemochromatosis

HFE_3

0.28

0.37

0.41

 NM_001074

UDP glucuronosyltransferase 2 family, polypeptide B7, 8, 10, 11

UGT2B7_8_10_11

0.29

0.41

0.91

 NM_000963

Cyclooxygenase 2

COX2

0.32

0.45

0.98

 NM_030753

Wingless-type MMTV integration site family, member 3

WNT3

0.33

0.32

0.34

 NM_001880

Activating transcription factor 2

ATF2

3.08

1.88

0.41

DHA 24 h

 NM_000778

Cytochrome P450, family 4, subfamily A, polypeptide 11

CYP4A11

0.07

0.10

0.12

 NM_000848

Glutathione S-transferase mu 2

GSTM2

0.12

0.11

0.11

 NG_002601

UDP glucuronosyltransferase 1 family, polypeptide A3

UGT1A3_4_5

2.24

0.60

0.09

 NM_004324

BCL2-associated X protein

BAX_2

2.25

2.26

0.53

 NM_000146

Ferritin

FTL

2.43

0.84

0.04

 NM_000765

Cytochrome P450, family 3, subfamily A, polypeptide 7

CYP3A7

3.02

3.20

0.43

 NM_014465

Sulfotransferase family 1B, member 1

SULT1B1

3.02

3.60

0.52

  1. Data are presented as fold change (FC) compared to the respective ethanol control for each experiment. A FC ≥2 was defined as gene up-regulation whereas a FC ≤0.33 was used as cut-off for down-regulated genes. Two-tailed t test was performed using Excel software
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Genes & Nutrition

ISSN: 1865-3499

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