Fig. 6From: Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetinFisetin inhibits 5-LOX activity. Peripheral blood mononuclear leukocytes (PBML) were pre-incubated with the indicated doses of fisetin prior to the addition of arachidonic acid for 10–15 min. 5-LOX activity was determined from EIA quantitation of the 5-LOX product leukotriene B4 [14]. NDGA was used as a positive control for 5-LOX inhibition (IC50 = 0.076)Back to article page