Skip to main content
Fig. 10 | Genes & Nutrition

Fig. 10

From: CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

Fig. 10

LPS induces liver injury in chronic ethanol-fed wild type (WT) mice but not in CYP2E1 knockout mice (KO). a content of CYP2E1; b CYP2E1 catalytic activity (oxidation of p-nitrophenol); c levels of TBARs; d serum ALT and AST levels in saline-treated dextrose-fed and ethanol-fed WT and KO mice and in LPS-treated dextrose-fed and ethanol-fed WT and KO mice. Note that LPS increases transaminase levels in the ethanol-fed WT but not the ethanol-fed CYP2E1 KO mice; e triglyceride levels. Note that ethanol increases the content of triglycerides in livers from WT mice but not CYP2E1 KO mice and that LPS has no effect on the ethanol-induced steatosis; f Liver pathology of ethanol plus LPS treated WT mice and CYP2E1 KO mice. Note that liver injury is produced by LPS in the ethanol-fed WT mice but not in the ethanol-fed CYP2E1 KO mice

Back to article page

Genes & Nutrition

ISSN: 1865-3499

Contact us