Fig. 12From: CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunctionThe mitochondrial permeability transition inhibitor, cyclosporine A (CsA) lowers LPS plus pyrazole-induced liver injury (a, b), the increase in mitochondrial swelling (decrease in absorbance at 540 nm) (c), and the elevated formation of 4-HNE and 3-NT protein adducts (d)Back to article page