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Fig. 4 | Genes & Nutrition

Fig. 4

From: CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

Fig. 4

Pyrazole potentiates TNFα hepatotoxicity and oxidative stress in mice. Mice were treated with either saline or pyrazole alone or TNFα alone or pyrazole plus TNFα followed by assays for a serum ALT/AST, b histopathology (arrows show necrotic zones), c lipid peroxidation as reflected by levels of TBARs, and d GSH levels. TBARs and GSH were determined in liver cell lysates and in isolated mitochondrial fractions

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Genes & Nutrition

ISSN: 1865-3499

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