Skip to main content
Fig. 7 | Genes & Nutrition

Fig. 7

From: CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

Fig. 7

Treatment with TNFα plus pyrazole causes mitochondrial injury as reflected by a increased mitochondrial swelling (decreased absorbance at 540 nm) or b decreased mitochondrial membrane potential as assayed by succinate-dependent decline in rhodamine 123 fluorescence. In a, the increased swelling produced by TNFα plus pyrazole is prevented by cyclosporine A (CsA), an inhibitor of the mitochondrial permeability transition

Back to article page