Fig. 1From: Alcohol consumption impairs hepatic protein trafficking: mechanisms and consequencesAlcohol-induced defects in hepatic trafficking. Secretion and delivery of newly synthesized basolateral proteins is impaired in ethanol-exposed hepatocytes (step 1). Also, three major steps in the itineraries of various receptors are impaired by ethanol metabolism: transport of newly synthesized receptors from the Golgi to the basolateral membrane (step 1); receptor internalization from the plasma membrane (step 2); and recycling of receptors from recycling endosomes (RE) back to the cell surface (step 3). EE early endosome; RE recycling endosome; lys lysosome; BC bile canaliculusBack to article page