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Fig. 1 | Genes & Nutrition

Fig. 1

From: Alcohol consumption impairs hepatic protein trafficking: mechanisms and consequences

Fig. 1

Alcohol-induced defects in hepatic trafficking. Secretion and delivery of newly synthesized basolateral proteins is impaired in ethanol-exposed hepatocytes (step 1). Also, three major steps in the itineraries of various receptors are impaired by ethanol metabolism: transport of newly synthesized receptors from the Golgi to the basolateral membrane (step 1); receptor internalization from the plasma membrane (step 2); and recycling of receptors from recycling endosomes (RE) back to the cell surface (step 3). EE early endosome; RE recycling endosome; lys lysosome; BC bile canaliculus

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