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Table 1 Effects of acute ethanol treatment (6 g/kg body weight, bolus) at 3 and 12 h, with and without SAMe

From: Gene expression modifications in the liver caused by binge drinking and S-adenosylmethionine feeding. The role of epigenetic changes

Treatment

Time

(h)

UAL

(mg %)

BAL

(mg %)

ALT

(U/L)

Path score

N

Ethanol

3

453.33 ± 56.66

347.86 ± 68.03

50.75 ± 2.9

0

4

Dextrose

3

0

0

41.25 ± 3.1

0

4

Ethanol

12

33.4 ± 15.5

29 ± 17.39

54 ± 3.2

0

3

Dextrose

12

0

0

50 ± 4

0

3

Ethanol + SAMe

Dextrose + SAMe

3

3

123 ± 48

0

138 ± 60

0

142 ± 67

50 ± 4

0

0

3

3

Ethanol + SAMe

Dextrose + SAMe

12

12

51 ± 24

0

39 ± 63

0

66 ± 24

62 ± 32

0

0

3

3

  1. Note that SAMe reduced the 3 h blood alcohol levels, and increased the 3 h ALT levels, when compared to the dextrose controls. The alcohol + dextrose treated results are reprinted from Bardag-Gorce et al. [1], with permission from WILEY InterScience