Gene expression modifications in the liver caused by binge drinking and S-adenosylmethionine feeding. The role of epigenetic changes

Table 2 Gene expression changes post 3 h ethanol bolus and the effects of SAMe on these changes

Gene symbol	Ratio			Gene name
Gene symbol	Alcohol + SAMe vs. Alcohol	SAMe vs. Dextrose	Alcohol vs. Dextrose	Gene name
Aldh6a1	−1.79	nc	nc	Aldehyde dehydrogenase 6
Igf2bp3	−1.83	−3.41	2.3	Insulin-like growth factor binding protein
Bhmt	−1.89	nc	1.7	Betaine-homocysteine methyltransferase
Cth	−2.31	−1.97	nc	Cystathionase
Mat2a	−2.33	−2.48	nc	Methionine adenosyltransferase
Fox n3	−2.43	nc	2.0	Foxhead box N3
Jun	−2.79	−2.43	nc	Jun oncogene
Tnfrsf9	−3.03	−5.17	nc	TNF receptor 9
Ahcyl	−3.16	−2.46	nc	S-adenosylmethyl transferase hydrolase
Tgfbrl	−3.18	−3.71	nc	TGF beta receptor 1
Pcaf	−3.18	nc	nc	p300/cBP associated factor
Rxra	−3.19	−2.35	nc	Retinoid X receptor alpha
Tgfbr2	−12.3	−6.82	nc	TGF beta receptor
Igf2r	nc	−1.77	nc	IgF 2 receptor
Hzafy2	nc	−2.31	nc	H2A histone Y2
Srebfl	nc	−2.57	nc	Sterol regulatory eleven binding factor
Fasn	nc	−3.2	nc	Fatty acid synthase
Adh4	nc	−3.29	nc	Alcohol dehydrogenase 4
Foxa2	nc	−3.32	−3.39	Foxhead box A2
FoxK2	nc	−5.28	nc	Foxhead box K2
HDAC2	nc	nc	−1.9	Histone deacetylase 2
FOXO1a	nc	nc	−2.1	Foxhead box 1 a
FOXOp1	nc	−2	nc	Foxhead box p1

ISSN: 1865-3499