Gene expression modifications in the liver caused by binge drinking and S-adenosylmethionine feeding. The role of epigenetic changes

Table 5 Selected genes where the expression changed at 3 and 12 h post ethanol bolus

Gene title	Gene symbol	Ratio
Gene title	Gene symbol	3 h	12 h
early growth response 1	Egr1	2.51	13.09
insulin-like growth factor binding protein 1	Igfbpl	17.51	10.78
S100 calcium binding protein AS (calgranulin	S100a8	2.00	6.68
fibroblast growth factor 21	Fgf21	−1.96	5.78
chemokine (C-X-C motif) ligand 12	Cxcl12	31.34	3.34
interleukin 1 receptor, type I	111 r1	1.54	3.32
FK506 binding protein 5	FkbpS	3.73	3.16
claudin 1	Cldnl	2.95	2.99
forkhead box A3	Foxa3	1.95	2.97
signal transducer and activator of transcription	Stat3	3.46	2.71
cyclin-dependent kinase inhibitor 1A	Cdknla	6.45	2.45
Jun-B oncogene	Junb	2.53	2.23
connective tissue growth factor	Ctgf	2.46	2.01
transferrin receptor	Tfrc	1.69	1.89
G protein-coupled receptor 116	Gpr116	2.36	1.79
junction adhesion molecule 2	Jam2	1.92	1.79
nuclear transcription factor-Y beta	Nfyb	−3.01	1.71
zinc finger protein 354A	Zfp354a	10.78	1.69
protein tyrosine phosphatase, receptor-type,	Ppfibp2	−2.16	−1.75
glutamate cysteine ligase, modifier subunit	Gclm	−1.85	−2.01
Prostaglandin E receptor 3 (subtype EP3)	Ptger3	−1.64	−2.14
epidermal growth factor receptor	Egfr	2.03	−2.28
fatty acid synthase	Fasn	2.13	−3.18
D site albumin promoter binding protein	Dbp	−1.75	−3.53
serine dehydratase	Sds	3.66	−4.41
stearoyl-Coenzyme A desaturase 1	Scd1	1.58	−9.38

ISSN: 1865-3499