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Table 4 Master regulators identified by transcriptomic analysis

From: Modulation of gene expression in endothelial cells by hyperlipaemic postprandial serum from healthy volunteers

Transcription factor

Processes

P value

Regulated genes

Nb

Examples

HNF-4α

Induction of apoptosis via death domain receptors

2.52E-143

78

LRP5, APOC3, NR1I2, PXR, ABG1, CIP1B1, CYP3A5

Energy metabolism

Response to chemical stimulus

SP1

Neurotransmitter uptake

6.10E-76

42

EDNRB, KRT16, TNNT2, PGE2R2, PGF2aR, nAChR alpha-5 and alpha-4

Intermediate filament cytoskeleton organization and biogenesis

Ketone body biosynthetic process

P53

DNA damage response, signal transduction resulting in induction of apoptosis

1.51E-37

21

BCL2L1, CREBBP, CDC6, CHEK2, DAXX, BCL2A1, BBC3

Regulation of mitochondrial membrane permeability

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

c-Myc

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

9.74E-36

20

BBC3, NOTCH1, BCL-3

Induction of apoptosis by intracellular signals

Release of cytochrome c from mitochondria

AP-1

Cell death

1.58E-28

16

CBP, DAXX, IL-3

Regulation of apoptosis

Regulation of apoptosis

c-Jun

Regulation of survival gene product activity

9.91E-27

15

CBP, DAXX, IL-3

Regulation of biological quality

Catecholamine uptake during transmission of nerve impulse

CREB1

Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

6.16E-25

14

IL-4, NPR1, SOX15

Regulation of cellular metabolic process

Regulation of transcription

ESR1

Steroid hormone receptor signalling pathway

3.80E-23

13

ABCC11, CYP1B1, CYP7B1

Oestrogen receptor signalling pathway

Regulation of transcription, DNA-dependent

HNF1-alpha

Catecholamine transport

3.80E-23

13

APOC3, Fibrinogen alpha, Anithrombin III

Positive regulation of cellular process

Catecholamine uptake during transmission of nerve impulse

NF-kB

Regulation of apoptosis

2.33E-21

12

SOD2, DAXX, Pim-2

Response to stress

Regulation of programmed cell death

  1. Transcription factors identified by MetaCore are presented. Transcription factors are organized by a major biological process in which they are involved, P value assigned by MetaCore, number of genes present in the array that they potentially regulate and examples of these genes