Transcription factor | Processes | P value | Regulated genes | |
---|---|---|---|---|
Nb | Examples | |||
HNF-4α | Induction of apoptosis via death domain receptors | 2.52E-143 | 78 | LRP5, APOC3, NR1I2, PXR, ABG1, CIP1B1, CYP3A5 |
Energy metabolism | ||||
Response to chemical stimulus | ||||
SP1 | Neurotransmitter uptake | 6.10E-76 | 42 | EDNRB, KRT16, TNNT2, PGE2R2, PGF2aR, nAChR alpha-5 and alpha-4 |
Intermediate filament cytoskeleton organization and biogenesis | ||||
Ketone body biosynthetic process | ||||
P53 | DNA damage response, signal transduction resulting in induction of apoptosis | 1.51E-37 | 21 | BCL2L1, CREBBP, CDC6, CHEK2, DAXX, BCL2A1, BBC3 |
Regulation of mitochondrial membrane permeability | ||||
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | ||||
c-Myc | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | 9.74E-36 | 20 | BBC3, NOTCH1, BCL-3 |
Induction of apoptosis by intracellular signals | ||||
Release of cytochrome c from mitochondria | ||||
AP-1 | Cell death | 1.58E-28 | 16 | CBP, DAXX, IL-3 |
Regulation of apoptosis | ||||
Regulation of apoptosis | ||||
c-Jun | Regulation of survival gene product activity | 9.91E-27 | 15 | CBP, DAXX, IL-3 |
Regulation of biological quality | ||||
Catecholamine uptake during transmission of nerve impulse | ||||
CREB1 | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 6.16E-25 | 14 | IL-4, NPR1, SOX15 |
Regulation of cellular metabolic process | ||||
Regulation of transcription | ||||
ESR1 | Steroid hormone receptor signalling pathway | 3.80E-23 | 13 | ABCC11, CYP1B1, CYP7B1 |
Oestrogen receptor signalling pathway | ||||
Regulation of transcription, DNA-dependent | ||||
HNF1-alpha | Catecholamine transport | 3.80E-23 | 13 | APOC3, Fibrinogen alpha, Anithrombin III |
Positive regulation of cellular process | ||||
Catecholamine uptake during transmission of nerve impulse | ||||
NF-kB | Regulation of apoptosis | 2.33E-21 | 12 | SOD2, DAXX, Pim-2 |
Response to stress | ||||
Regulation of programmed cell death |