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Table 2 Colon Nrf2 target genes responding to selenium supply as measured by microarray analysis

From: Nrf2 target genes are induced under marginal selenium-deficiency

Gene name

Description

Acc. number

P value

FC

Reference

Abcb1a (Mdr3)

ATP-binding cassette, subfamily B (MDR/TAP), member 1A

NM_011076

0.139

1.11

 

Abcb1b (Mdr1)

ATP-binding cassette, subfamily B (MDR/TAP), member 1B

NM_011075

0.138

1.09

[24]

Abcc1 (Mrp1)

ATP-binding cassette, subfamily C (CFTR/MRP), member 1

NM_008576

0.0003

0.83

[15]

Abcc4 (Mrp4)

ATP-binding cassette, subfamily C (CFTR/MRP), member 4

NM_001033336

0.004

1.23

[36]

Abcg5

ATP-binding cassette, subfamily G (WHITE), member 5

NM_031884

0.028

1.22

[47]

Aldh1a1

Aldehyde dehydrogenase family 1, subfamily A1

NM_013467

0.133

1.21

[34]

Aldh1a3

Aldehyde dehydrogenase family 1, subfamily A3

NM_053080

0.040

1.20

 

Aldh1a7

Aldehyde dehydrogenase family 1, subfamily A7

NM_011921

0.028

1.12

[34, 47]

Aldh3a2

Aldehyde dehydrogenase family 3, subfamily A2

NM_007437

0.120

1.16

[47]

Aldh9a1

Aldehyde dehydrogenase 9, subfamily A1

NM_019993

0.002

1.31

 

Blvrb

Biliverdin reductase B (flavin reductase (NADPH))

NM_144923

0.106

1.14

[40]

Cat

Catalase

NM_009804

0.760

1.03

[11]

Ces1

Carboxylesterase 1

NM_021456

0.109

1.20

[47]

Ces2

Carboxylesterase 2

NM_145603

0.004

0.72

[47]

Ephx1

Epoxide hydrolase 1, microsomal

NM_010145

0.563

1.04

[6]

Esm1

Endothelial cell-specific molecule 1

NM_023612

0.011

1.16

[41]

Fth1

Ferritin heavy chain 1

NM_010239

0.098

1.29

[41]

G6pdx

Glucose-6-phosphate dehydrogenase X-linked

NM_008062

0.057

1.19

[54]

Gclc

Glutamate-cysteine ligase, catalytic subunit

NM_010295

0.048

0.80

[37]

Gclm

Glutamate-cysteine ligase, modifier subunit

NM_008129

0.038

0.88

[37]

Gpx2

Glutathione peroxidase 2

NM_030677

0.065

0.67

[5]

Gsr

Glutathione reductase 1

NM_010344

0.401

1.12

[54]

Gss

Glutathione synthetase

NM_008180

0.044

0.74

[33]

Gsta1

Glutathione S-transferase, alpha 1 (Ya)

NM_008181

0.264

1.15

[21]

Gsta2

Glutathione S-transferase, alpha 2 (Yc2)

NM_008182

0.073

1.15

[21]

Gsta3

Glutathione S-transferase, alpha 3

NM_001077353

0.329

1.12

[21]

Gsta4

Glutathione S-transferase, alpha 4

NM_010357

0.001

1.18

[21]

Gstm1

Glutathione S-transferase, mu 1

NM_010358

0.272

1.22

[21]

Gstm5

Glutathione S-transferase, mu 5

NM_010360

0.027

1.30

[21]

Gstm7

Glutathione S-transferase, mu 7

NM_026672

0.080

1.29

 

Gstp1

Glutathione S-transferase, pi 1

NM_013541

0.141

0.80

[19]

Gusb

Glucuronidase, beta

BC004616

0.013

1.15

 

Hmox1

Heme oxygenase (decycling) 1

NM_010442

0.025

1.09

[11]

Mt1

Metallothionein 1

NM_013602

0.010

1.32

[59]

Mt2

Metallothionein 2

NM_008630

0.019

1.57

[59]

Nat13

N-acetyltransferase 13

NM_028108

0.001

1.21

 

Nat3

N-acetyltransferase 3

NM_008674

0.002

1.29

 

Nat8 l

N-acetyltransferase 8-like

NM_001001985

0.038

1.15

 

Nqo1

NAD(P)H dehydrogenase, quinone 1

NM_008706

0.589

1.04

[11, 56]

Pgd

Phosphogluconate dehydrogenase

BC011329

0.007

0.72

[54]

Pir

Pirin

NM_027153

0.312

1.10

[18]

Prdx1

Peroxiredoxin 1

NM_011034

0.092

1.32

[20, 27]

Prdx2

Peroxiredoxin 2

NM_011563

0.229

1.20

 

Prdx4

Peroxiredoxin 4

NM_016764

0.026

1.34

 

Sod1

Superoxide dismutase 1, soluble

NM_011434

0.012

1.54

[11]

Sqstm1

Sequestosome 1 (A170 stress protein)

NM_011018

0.037

1.28

[20]

Srxn1

Sulfiredoxin 1 homolog

NM_029688

0.128

1.17

[4]

Sult1b1

Sulfotransferase family 1B, member 1

NM_019878

0.016

1.26

[2]

Sult1c2

Sulfotransferase family, cytosolic, 1C, member 2

NM_026935

0.039

1.21

[2]

Tkt

Transketolase

NM_009388

0.904

1.01

[18]

Txn1

Thioredoxin 1

NM_011660

0.377

1.11

[26]

Txn2

Thioredoxin, mitochondrial protein

U85089

0.154

1.12

[26]

Txnrd1

Thioredoxin reductase 1 (Txnrd1), transcript variant 1

NM_001042523

0.572

0.94

[17]

Ugdh

UDP-glucose dehydrogenase

NM_009466

0.300

1.14

[47]

Ugp2

UDP-glucose pyrophosphorylase 2

NM_139297

0.753

1.02

[47]

Ugt1a1

UDP glucuronosyltransferase 1 family, polypeptide A1

NM_201645

0.981

1.00

[60]

Ugt1a6b

UDP glucuronosyltransferase 1 family, polypeptide A6B

NM_201410

0.217

1.26

[11]

Ugt2b34

UDP glucuronosyltransferase 2 family, polypeptide B34

NM_153598

0.004

0.82

[47]

Ugt2b37

UDP glucuronosyltransferase 2 family, polypeptide B37

NM_053215

0.009

1.26

 

Ugt2b5

UDP glucuronosyltransferase 2 family, polypeptide B5

NM_009467

0.020

1.20

 
  1. Genes are sorted based on gene name. Fold change (FC) numbers in bold indicate an up-regulation in selenium-deficiency (FC > 1.1). Gene names in bold indicate analysis by qPCR. Gene names in italic point to selenoprotein genes