Table 3 Metabolic and cellular processes affected by bilberry anthocyanin-rich extract in the liver of apo E−/− mice using Pathway Miner analyses
Pathways | Total (n) | Up-regulated genes (n) | Down-regulated genes (n) |
|---|---|---|---|
Babelomics | |||
Metabolic process | |||
 Energy and lipid metabolism | |||
  Oxidative phosphorylation | 9 | 6 | 3 |
  Arachidonic acid metabolism | 11 | 5 | 6 |
  Fatty acid metabolism | 11 | 6 | 5 |
  Glycerophospholipid metabolism | 10 | 5 | 5 |
  Glycerolipid metabolism | 6 | 4 | 2 |
  Bile acid biosynthesis | 3 | 2 | 1 |
  Biosynthesis of steroids | 3 | 3 | 0 |
  Fatty acid biosynthesis | 2 | 2 | 0 |
Cellular process | Â | Â | Â |
 Cell migration and communication | |||
  Regulation of actin cytoskeleton | 31 | 19 | 12 |
  Cell Communication | 21 | 14 | 7 |
  Focal adhesion | 27 | 17 | 10 |
  Leukocyte transendothelial migration | 18 | 9 | 9 |
  Cell adhesion molecules (CAMs) | 17 | 7 | 10 |
 Inflammation | |||
  Natural killer cell mediated cytotoxicity | 13 | 7 | 6 |
  T cell receptor signalling pathway | 12 | 6 | 6 |
  Complement and coagulation cascades | 11 | 6 | 5 |
 Signalling | |||
  Neuroactive ligand-receptor interaction | 46 | 25 | 21 |
  MAPK signalling pathway | 36 | 16 | 20 |
  Cytokine-cytokine receptor interaction | 23 | 14 | 9 |
  Jak-STAT signalling pathway | 15 | 10 | 5 |
GenMAPP | |||
Metabolic process | |||
 Statin pathway | 5 | 4 | 1 |
 Electron Transport Chain | 5 | 3 | 2 |
 Steroid Biosynthesis | 3 | 1 | 2 |
 Mitochondrial fatty acid betaoxidation | 3 | 3 | 0 |
Cellular process | |||
 Regulation of actin cytoskeleton | 24 | 14 | 10 |
 Integrin-mediated cell adhesion | 17 | 6 | 11 |
 TGF Beta Signalling Pathway | 10 | 6 | 4 |
 Nuclear receptors | 6 | 3 | 3 |
 Inflammatory Response Pathway | 3 | 2 | 1 |
 Complement Activation Classical | 2 | 0 | 2 |
Biocarta | Â | Â | Â |
Metabolic process | Â | Â | Â |
 SREBP control of lipid synthesis | 3 | 2 | 1 |
 FXR and LXR regulation of cholesterol metabolism | 2 | 2 | 0 |
Cellular process | |||
 Nuclear receptors in lipid metabolism and toxicity | 11 | 8 | 3 |
 PDGF signalling pathway | 8 | 5 | 3 |
 TNFR1 signalling pathway | 6 | 4 | 2 |
 CXCR4 signalling pathway | 6 | 4 | 2 |
 IL-10 anti-inflammatory signalling pathway | 3 | 2 | 1 |