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Table 4 Genotype frequencies in Korean patients with colorectal cancer and controls stratified according to disease subsite

From: Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer

Gene/SNP

Colon cancer

Rectal cancer

Case/cont

ORa (95% CI)

ORb (95% CI)

Case/cont

ORa (95% CI)

ORb (95% CI)

SOD2

RS4880

 AA

305/583

1.0

1.0

278/583

1.0

1.0

 GA

66/128

0.99 (0.72–1.38)

0.96 (0.68–1.36)

65/128

1.08 (0.78–1.51)

1.04 (0.74–1.48)

 GG

6/9

1.26 (0.44–3.58)

1.45 (0.49–4.30)

3/9

0.69 (0.19–2.59)

0.79 (0.20–3.05)

P for trend

 

0.851

0.905

 

0.867

0.961

SELS

RS34713741

 CC

143/283

1.0

1.0

111/283

1.0

1.0

 CT

203/351

1.12 (0.86–1.47)

1.09 (0.82–1.44)

187/351

1.35 (1.01–1.79)

1.40 (1.04–1.89)

 TT

23/70

0.65 (0.39–1.09)

0.63 (0.37–1.07)

40/70

1.46 (0.93–2.29)

1.57 (0.98–2.51)

P for trend

 

0.525

0.397

 

0.032

0.018

SEPP1

RS3877899

 CC

369/710

1.0

1.0

337/710

1.0

1.0

 CT

1/1

0.266 (0.16–43.2)

3.21 (0.20–52.7)

2/1

4.74 (0.42–53.1)

5.35 (0.47–61.5)

SEPP1

RS7579

 CC

190/363

1.0

1.0

176/363

1.0

1.0

 CT

121/239

0.95 (0.72–1.26)

0.95 (0.70–1.27)

111/239

0.94 (0.70–1.25)

0.99 (0.73–1.36)

 TT

32/67

0.90 (0.57–1.42)

0.96 (0.59–1.57)

26/67

0.78 (0.48–1.27)

0.86 (0.51–1.45)

P for trend

 

0.634

0.863

 

0.331

0.728

SEP15

RS5845

 GG

368/707

1.0

1.0

333/707

1.0

1.0

 GA

14/25

1.08 (0.55–2.10)

1.17 (0.58–2.35)

15/25

1.24 (0.64–2.38)

1.33 (0.67–2.64)

P

 

0.827

0.658

 

0.524

0.411

SEP15

RS5859

 CC

369/705

1.0

1.0

329/705

1.0

1.0

 CT

14/25

1.07 (0.55–2.09)

1.16 (0.58–2.34)

15/25

1.25 (0.65–2.41)

1.34 (0.68–2.66)

P

P for trend

0.84

0.671

 

0.507

0.399

GPX4

RS713041

 CC

160/275

1.0

1.0

131/275

1.0

1.0

 CT

161/325

0.85 (0.65–1.12)

0.93 (0.70–1.71)

159/325

1.03 (0.78–1.37)

1.07 (0.79–1.44)

 TT

50/97

0.89 (0.60–1.32)

1.01 (0.67–1.55)

42/97

0.90 (0.59–1.37)

0.99 (0.64–1.56)

P for trend

 

0.367

0.906

 

0.74

0.874

GPX1

RS1050450

 CC

385/547

1.0

1.0

271/547

1.0

1.0

 CT + TT

53/121

0.80 (0.56–1.14)

0.89 (0.61–1.29)

48/121

0.80 (0.55–1.15)

0.89 (0.60–1.30)

  1. Multivariate logistic regression was used to assess the relationship between each genetic variant and CRC risk. Adjusted mean odds ratios (OR) with 95% confidence limits are shown and those in bold indicate they are statistically significant. P for trend values (and P values for rs 5845 and 5859 where there are only two values) are indicated in italics
  2. aAdjusted for age and sex
  3. bAdjusted for age, sex, intake of aspirin, intake of multivitamin, family history of colorectal cancer, smoking, alcohol, intake of red meat, vegetables and fruits, and physical activities
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Genes & Nutrition

ISSN: 1865-3499

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