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Table 6 Genotype frequencies in male Korean patients with colorectal cancer and controls stratified according to disease subsite

From: Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer

Gene/SNP

Colon cancer

Rectal cancer

Case/Cont

ORa (95% CI)

ORb (95% CI)

Case/Cont

ORa (95% CI)

ORb (95% CI)

SOD2

RS4880

 AA

179/318

1.0

1.0

164/318

1.0

1.0

 GA + GG 

43/81

0.44 (0.11–1.71)

0.58 (0.14–2.34)

36/81

0.91 (0.16–5.24)

0.90 (0.15–5.37)

SELS

RS34713741

 CC

86/151

1.0

1.0

65/151

1.0

1.0

 CT

116/200

1.00 (0.71–1.42)

0.90 (0.62–1.31)

112/200

1.29 (0.88–1.87)

1.32 (0.88–1.97)

 TT

13/39

0.58 (0.29–1.15)

0.52 (0.25–1.06)

20/39

1.16 (0.63–2.16)

1.12 (0.58–5.18)

P for trend

 

0.284

0.128

 

0.335

0.402

SEPP1

RS7579

 CC

94/192

1.0

1.0

101/192

1.0

1.0

 CT

82/134

1.23 (0.85–1.78)

1.18 (0.80–1.76)

68/134

0.91 (0.62–1.33)

0.93 (0.62–1.40)

 TT

19/41

0.94 (0.52–1.71)

0.90 (0.47–1.71)

13/41

0.56 (0.28–1.09)

0.56 (0.27–1.15)

P for trend

 

0.703

0.772

 

0.126

0.212

SEP15

RS5845

 GG

216/390

1.0

1.0

189/390

1.0

1.0

 GA

8/12

1.20 (0.48–2.99)

1.41 (0.52–3.83)

12/12

2.01 (0.88–4.58)

2.47 (0.99–6.19)

P

 

0.695

0.506

 

0.098

0.052

SEP15

RS5859

      

 CC

217/390

1.0

1.0

187/390

1.0

1.0

 CT

8/12

1.19 (0.48–2.97)

1.40 (0.51–3.81)

12/12

2.03 (0.89–4.63)

2.51 (1.00–6.28)

 P

 

0.702

0.513

 

0.093

0.049

GPX4

RS713041

 CC

103/150

1.0

1.0

81/150

1.0

1.0

 CT

86/184

0.68 (0.48–0.97)

0.79 (0.54–1.16)

85/184

0.86 (0.59–1.24)

0.91 (0.61–1.37)

 TT

28/48

0.85 (0.50–1.44)

1.04 (0.58–1.87)

26/48

0.98 (0.56–1.70)

1.19 (0.65–2.15)

 P for trend

 

0.17

0.673

 

0.692

0.803

GPX1

RS1050450

 CC

165/293

1.0

1.0

160/293

1.0

1.0

 CT + TT

35/67

0.93 (0.59–1.46)

1.13 (0.70–1.83)

25/67

0.69 (0.42–1.14)

0.78 (0.45–1.32)

  1. Multivariate logistic regression was used to assess the relationship between each genetic variant and CRC risk. Adjusted mean odds ratios (OR) with 95% confidence limits are shown and those in bold indicate statistical significance. P for trend values (and P values for rs 5845 and 5859 where there are only two values) are indicated in italics
  2. aAdjusted for age and sex
  3. bAdjusted for age, sex, intake of aspirin, intake of multivitamin, family history of colorectal cancer, smoking, alcohol, intake of red meat, vegetables and fruits, and physical activities
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Genes & Nutrition

ISSN: 1865-3499

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