Table 2 A list of selected significantly up-regulated and down-regulated genes in HepG2 cells treated with methanolic extracts of T. indica fruit pulp that may be related to stress response (A), lipid metabolic processes (B) and others (C)
Genebank ID | Protein (gene name) | Fold change (treated vs. untreated) |
|---|---|---|
Stress response | ||
NM_176870 | Metallothionein 1 M (MT1M) | 5.21 |
NM_005949 | Metallothionein 1F (MT1F) | 2.35 |
NM_005952 | Metallothionein 1X (MT1X) | 1.68 |
NM_145740 | Glutathione S-transferases (GSTA1) | 2.80 |
NM_000846 | Glutathione S-transferases (GSTA2) | 1.60 |
NM_183239 | Glutathione S-transferases (GSTO2) | 1.73 |
Lipid metabolic process | ||
NM_000482 | Apolipoprotein A-IV (APOA4) | 2.31 |
NM_052968 | Apolipoprotein A-V (APOA5) | 1.90 |
NM_022436 | ATP-binding cassette, subfamily G (WHITE), member 5 (ABCG5) | 1.84 |
NM_000253 | Microsomal triglyceride transfer protein (MTTP) | −1.80 |
Others | ||
NM_000921 | Phosphodiesterase 3A, cGMP-inhibited (PDE3A) | −5.10 |
NM_000499 | Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) | −3.61 |
NM_004590 | Chemokine (C–C motif) ligand 16 (CCL16) | −4.36 |
NM_004219 | Pituitary tumour-transforming 1 (PTTG1) | −2.93 |
NM_199246 | Cyclin G1 (CCNG1) | −2.31 |
NM_004701 | Cyclin B2 (CCNB2) | −2.24 |
NM_004354 | Cyclin G2 (CCNG2) | −1.97 |
NM_001237 | Cyclin A2 (CCNA2) | −1.93 |
NM_001786 | Cell division cycle 2, G1 to S and G2 to M (CDC2) | −1.85 |
NM_031966 | Cyclin B1 (CCNB1) | −1.78 |