Fig. 1
From: Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer
Two-pathway model of ovarian carcinogenesis. High-grade tumors grow rapidly without identifiable precursor lesions, and more frequently harbor P53 mutations. In contrast, low-grade tumors grow more slowly and share molecular characteristics with low-malignant potential (LMP) tumors, such as K-Ras, BRAF, and PTEN mutations. Additional alterations, including angiogenesis and achievement of potential for invasion and metastasis, are required for tumor progression to invasive ovarian cancers in both pathways