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Fig. 6 | Genes & Nutrition

Fig. 6

From: Dietary chalcones with chemopreventive and chemotherapeutic potential

Fig. 6

Involvement of naturally occurring chalcone derivatives in apoptotic cell death. Chalcones potentiate the extrinsic apoptotic pathway: chalcones enhance the apoptosis-inducing potential of TRAIL partially by increased expression of death receptors DR4 and DR5 (chalcones 2, 5, 10, 15, 16, 18, 22). Chalcones are implicated in the intrinsic apoptotic pathway: chalcones target mitochondria either by disruption of the mitochondrial membrane potential (chalcones 2, 5) or by downregulation of anti-apoptotic proteins like Bcl-xL, Bcl-2, and upregulation of Bax and Bak (chalcones 16, 23, 40). Chalcones induce apoptosis via positive modulation of caspase-3 activity (chalcones 10, 15, 16, 23, 39). Arrows represent induction/activation and blunt-ended lines represent repression/inactivation. Abbreviations: TNFα tumor necrosis factor alpha, TRAIL TNF-related apoptosis-inducing ligand, FasL Fas ligand, FADD Fas-associated death domain, DD death domain, DED death effector domain, DISC death-inducing silencing complex, Casp caspase, Bid Bcl-2 interacting domain, Cyt cytochrome C. This figure was generated with ScienceSlides software

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