Dietary chalcones with chemopreventive and chemotherapeutic potential

Genes & Nutrition

Table 1 Semi-synthetic and synthetic chalcone derivatives as antiproliferative agents

Chalcone derivative	Parent natural product (if available)	Targeted cellular processes	References
15 dihydroartemisinin derivatives	Artemisinin (Artemisia annua)	Cell viability Cell proliferation apoptosis	[179]
21 derivatives polyoxygenated on the A ring	Tangeretin (Citrus)	Cell proliferation	[145]
Boronic acid CA-4 analogues:cis-6, trans-6	Combretastatin A4 (Combretum caffrum)	Cell proliferation Inhibition of tubulin assembly	[79]
4 analogues	Combretastatin A4 (Combretum caffrum)	Cell proliferation Inhibition of tubulin assembly angiogenesis	[78]
97 combretastatin-like chalcones	Combretastatin A4 (Combretum caffrum)	Cell viability Cell cycle Inhibition of tubulin assembly	[31]
65 derivatives with basis functionalities		Cell proliferation	[107]
19 methoxylated derivatives		Cell proliferation Cell viability inflammation	[8]
12 β-chlorovinyl derivatives		Cell proliferation inflammation	[7]
17 piperidinylchalcones derivatives		Cell proliferation Cell cycle	[106]
RVC-588 (4,4′-dihydroxychalcone)		Cell viability Cell proliferation Cell death	[156]
2′,4′,6′-tris(methoxymethoxy) chalcone		Cell proliferation	[95]
4′-(p-toluenesulfonylamido)-4-hydroxychalcone		Cell proliferation	[91]
JAI-51		Cell proliferation Cell cycle Inhibition of tubulin assembly	[10]
MDL-27048		Cell proliferation Cell cycle Inhibition of tubulin assembly	[69]
644 chalcone derivatives		Cell proliferation Cell cycle Inhibition of tubulin assembly	[87]

ISSN: 1865-3499