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Table 2 Plant polyphenols with anti-angiogenic properties

From: Dietary chalcones with chemopreventive and chemotherapeutic potential

Polyphenolic compound

Molecular target

References

Red wine polyphenols

VEGF, pro-MMP-2, (MT1)-MMP

[130, 132]

Green tea polyphenols

VEGF, MMP-2, MMP-9

[116]

Epigallocatechin-3-gallate

VEGF

[16]

Delphinidin

Cyanidin

VEGF

[131]

Methylophiopogonanone B

VEGF

[49]

Luteolin

VEGF

[6]

Wogonin

VEGF

[104, 105]

Genistein

VEGF, bFGF, uPA, PDGF-A, TF, MMP-2, MMP-9

[34, 46, 154, 164]

Apigenin

HIF-1, VEGF

[32]

Chrysin

HIF-1, VEGF

[37, 103]

Silibinin

MMP-2

[159]

Flavonoids (acacetin, apigenin, chrysin, genistein, kaempferol, morin, naringin, naringenin, rutin)

VEGF

[157]