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Table 2 Metabolic outcomes of normal-weight and obese women according to TNFA -308 G/A genotype

From: The -308 G/A polymorphism of the tumour necrosis factor-α gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women

 

Normal-weight, n = 88

Obese, n = 60

P-valuesa

GG

GA + AA

GG

GA + AA

BMI group

Genotype

Interaction

n

48

40

35

25

   

Glucose, mmol/L

4.56 (4.30–4.80)

4.48 (4.28–4.70)

4.78 (4.51–4.99)

4.84 (4.63–5.05)

0.007

0.716

0.647

Insulin, mU/L

5.79 (4.15–8.02)

5.30 (4.22–6.35)

10.70 (8.42–15.55)

12.51 (9.10–18.76)

<0.001

0.558

0.195

HOMA-IR

0.73 (0.52–1.01)

0.67 (0.53–0.81)

1.34 (1.08–1.98)

1.61 (1.19–2.33)

<0.001

0.572

0.203

TG, mmol/L

0.80 (0.60–1.05)

0.75 (0.60–1.03)

1.20 (0.65–1.60)

1.00 (0.90–1.50)

0.003

0.974

0.965

T–C, mmol/L

4.30 (3.85–4.95)

4.50 (4.08–5.10)

4.90 (4.40–5.80)

5.00 (4.40–5.70)

0.023

0.827

0.956

HDL–C, mmol/L

1.80 (1.60–2.00)

1.70 (1.60–2.00)

1.50 (1.35–1.85)

1.40 (1.10–1.60)

0.014

0.659

0.096

LDL-C, mmol/L

2.30 (1.85–2.70)

2.30 (1.85–2.80)

2.70 (2.25–3.50)

3.20 (2.60–3.50)

0.006

0.991

0.348

T-C/HDL-C ratio

2.53 (2.17–2.90)

2.67 (2.20–2.82)

3.29 (2.58–4.06)

3.82 (3.15–4.82)

<0.001

0.799

0.122

hsCRP, mg/L

1.6 (0.7–4.2)

1.4 (0.7–2.6)

8.1 (2.9–11.7)

6.3 (3.7–7.4)

<0.001

0.144

0.3403

  1. Values are median (interquartile range)
  2. HOMA-IR homeostasis model assessment–insulin resistance, TG triglycerides, T-C total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, T-C:HDL-C ratio total cholesterol:high-density lipoprotein cholesterol ratio, hsCRP high-sensitivity C-reactive protein
  3. aP-values are from a linear model testing the interaction between BMI group and TNFA -308 G/A genotype, adjusted for age
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Genes & Nutrition

ISSN: 1865-3499

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