Table 3 Relationship of the PON1-L55M and PON1-Q192R polymorphisms with the lipid profile of the normal-weight and obese groups
PON1–192 | PON1–55 | ||||||
|---|---|---|---|---|---|---|---|
QQ (IC 95%) | QR + RR (IC 95%) | P value | LL (IC 95%) | LM + MM (IC 95%) | P value | ||
TG (mg/dl) | Normal weight | 115 (90.1–147.4) | 111 (78.3–129.4) | 0.725 | 105 (82.6–126.9) | 125 (103.9–146.5) | 0.918 |
Obese subjects | 162 (88.1–211.4) | 171 (139.8–191.1) | 0.823 | 169 (132.7–195.3) | 166 (97–179.6) | 0.232 | |
TC (mg/dl) | Normal weight | 177 (157.7–191.1) | 177 (167.1–190.5) | 0.933 | 174 (164.9–182.7) | 184 (168.7–198.2) | 0.662 |
Obese subjects | 198 (182.7–219.6) | 199 (184.7–208.3) | 0.982 | 200 (185–207.3) | 195 (181.2–225.7) | 0.230 | |
HDL (mg/dl) | Normal weight | 52 (44.8–58.4) | 44 (39.8–48.2) | 0.254 | 51 (46.9–54.5) | 48 (40.7–58.5) | 0.364 |
Obese subjects | 41 (38.9–50.4) | 49 (39.8–48.2) | 0.315 | 42 (39.1–46.2) | 45 (40.7–58.5) | 0.365 | |
LDL (mg/dl) | Normal weight | 107 (73.8–163.7) | 109 (100.1–121) | 0.639 | 105 (97.1–113) | 115 (104.6–125.6) | 0.463 |
Obese subjects | 130 (121.8–145.5) | 127 (117–136.4) | 0.820 | 129 (119.2–137.7) | 123 (115.0–143.0) | 0.130 | |
Paraoxonase activity (nmol/min/ml) | Normal weight | 119 (73.8–163.7) | 211 (155.0–267.2) | 0.024 | 202 (144.1–259.2) | 135 (87.0–183.5) | 0.091 |
Obese subjects | 81 (35–127.9) | 200 (139.4–260.0) | 0.036 | 178 (115.0–240.4) | 152 (74.7–229.4) | 0.939 | |
Arylesterase activity (nmol/min/ml) | Normal weight | 81 (44.8–117.6) | 64 (39.0–88.2) | 0.392 | 74 (47.8–100.8) | 63 (30.8–95.7) | 0.594 |
Obese subjects | 98 (37.5–158.5) | 75 (47.6–101.9) | 0.391 | 85 (56.4–113.7) | 67 (11.8–121.1) | 0.531 | |