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Table 2 Selected significantly expressed genes in HepG2 cells in response to treatment with 0.4, 0.6 and 1.7 mg/ml of the extracts of A. occidentale shoots

From: Microarray analysis revealed different gene expression patterns in HepG2 cells treated with low and high concentrations of the extracts of Anacardium occidentale shoots

Gene ID

Gene name

Gene product

Fold change (0.4 mg/ml)

Fold change (0.6 mg/ml)

Fold change (1.7 mg/ml)

NM_005192

CDKN3

Cyclin-dependent kinase inhibitor 3

−2.7

−2.6

−10.5

AY605064

LOC100289612

Arsenic transactivated protein 1

−3.0

−3.6

−10.2

AK293146

DHFR

Dihydrofolate reductase

−2.4

−2.4

−10.0

NM_003384

VRK1

Vaccinia related kinase 1

−2.3

−2.6

−6.7

NM_001254

CDC6

Cell division cycle 6 homolog (S. cerevisiae)

−2.4

−2.7

−4.3

NM_030622

CYP2S1

Cytochrome P450, family 2, subfamily S, polypeptide 1

+1.8

+2.3

+3.5

NM_004961

GABRE

Gamma-aminobutyric acid (GABA) A receptor, epsilon

+1.6

+2.1

+2.7

NM_004217

AURKB

Aurora kinase B

−1.6

−1.6

−2.2

NM_000782

CYP24A1

Cytochrome P450, family 24, subfamily A, polypeptide 1

NR

−2.9

−27.8

NM_001792

CDH2

Cadherin 2, type 1, N-cadherin (neuronal)

NR

−1.8

−15.5

NM_001951

E2F5

E2F transcription factor 5, p130-binding

NR

−1.9

−5.5

NR_027676

BRCA1

Breast cancer 1, early onset

NR

−2.4

−5.1

NM_000236

LIPC

Lipase, hepatic

NR

−3.2

−4.7

NM_198433

AURKA

Aurora kinase A

NR

−1.5

−4.4

NM_001786

CDC2

Cell division cycle 2, G1 to S and G2 to M

NR

−2.5

−4.1

NM_001798

CDK2

Cyclin-dependent kinase 2

NR

−2.0

−3.2

NM_001237

CCNA2

Cyclin A2

NR

−1.7

−3.1

NM_000059

BRCA2

Breast cancer 2, early onset

NR

−2.0

−2.7

NM_000019

ACAT1

Acetyl-coenzyme A acetyltransferase 1

NR

−1.9

−2.6

NM_000075

CDK4

Cyclin-dependent kinase 4

NR

−1.8

−2.6

NM_001274

CHEK1

CHK1 checkpoint homolog (S. pombe)

NR

−1.8

−2.3

NM_000208

INSR

Insulin receptor

NR

+2.3

+2.6

NM_000596

IGFBP1

Insulin-like growth factor binding protein 1

NR

+3.7

+4.2

NM_004419

DUSP5

Dual specificity phosphatase 5

NR

+3.3

+9.1

NM_003667

LGR5

Leucine-rich repeat-containing G protein-coupled receptor 5

NR

NR

−16.4

NM_000321

RB1

Retinoblastoma 1

NR

NR

−7.6

NM_031966

CCNB1

Cyclin B1

NR

NR

−5.7

NM_000253

MTTP

Microsomal triglyceride transfer protein

NR

NR

−3.7

NM_002979

SCP2

Sterol carrier protein 2

NR

NR

−3.5

NM_004969

IDE

Insulin-degrading enzyme

NR

NR

−2.1

NM_000384

APOB

Apolipoprotein B

NR

NR

−2.0

NM_001013398

IGFBP3

Insulin-like growth factor binding protein 3

NR

NR

+8.0

NM_000527

LDLR

Low-density lipoprotein receptor

NR

NR

+3.6

NM_005952

MTIX

Metallothionein 1X

NR

NR

+2.8

NM_003102

SOD3

Superoxide dismutase 3, extracellular

NR

NR

+2.1

  1. Details of the GenBank accession number, name of the gene and its respective gene product, fold change difference between treated and non-treated cells and p values are included. NR Not regulated