Table 3 Gene ontology analysis of selected significantly regulated genes

Cellular process

CYP24A1, DHFR, CDH1, CDH2, CDC2, CDK2, CDK4, CDK5, CDK6, CDKN3, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CHEK1, RB1, AURKA, AURKB, BRCA1, BRCA2, IDE, LIPC, MTTP, SCP2, APOB, ACAT1

DUSP5, INSR, IRS2, SOD2, SOD3, LDLR

Biological regulation

CDH1, CDC2, CDK2, CDK4, CDK5, CDK6, CDKN3, CHEK1, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, E2F4, AURKA, RB1, CKS1B, PAK2, BRCA1, BRCA2, CSNK1G3, FZD4, FZD6, LIPC, APOB, APOBEC3F, APOH, MTTP, IDE

CDH4, CDKN2B, CDKN1A, APC2, IRS2, WNT6, FZD1, FZD7, FZD8, FZD9, FZD10, IGFBP1, IGFBP2, IGFBP3, IGFBP6, INSR, LDLR, SOD2

Metabolic process

CDH1, CCNH, CHEK1, CDK5, E2F4, CYP24A1, RB1, DHFR, BRCA1, LIPC, MAOB, MTTP, SCP2, ACAT1, APOB

APC2, SOD2, SOD3, INSR, LDLR

Response to stimuli

BRCA1, BRCA2, CHEK1, CDK5

IRS2, CDKN2D, SOD2, SOD3, CDKN2B, CDKN1A, MT1X

Establishment of localization

LIPC, MTTP, SCP2, APOB

LDLR

Developmental process

CDH2, RB1, CCNB2, BRCA1, SCP2, FZD6, CDK6, BRCA2, CCNF, DKK1, CDK5 E2F4, IDE, APOB, CDH1, FZD4

FZD7, CDK5R1, FZD9, IRS2, IGF2, CDKN2D, FZD10, CDKN1C, SOD2, FZD8, WNT6, FZD1, INSR

Multi-organism process

RB1

INSR, LDLR

Biological adhesion

CDH2, FZD6, CDK5, CDH1

CDH4

Reproductive process

SCP2, BRCA2, CHEK1, APOB

Multicellular organismal process

APOH, ACAT1, CDK5, E2F4

FZD9, LDLR

Rythmic process

CDK4

–

Growth

CCNB2, BRCA2

–

Pigmentation

–

SOD2

Binding

CYP24A1, CDH2, CDKN3, RB1, DHFR, CCNB1, CCNB2, BRCA1, LIPC, AURKA, CDC2, BRCC3, MTTP, SCP2, CDK2,CCNA2, APOH, CDK6, RBL2, BRCA2, ACAT1, CDK4, CHEK1, CCNE1, AURKB, CDK5, E2F4, IDE, APOB, CDH1, FZD4, CSNK1G2, CCNE2

CDH4, IGFBP2, IRS2, FZD10, SOD2, FZD8, WNT6, SOD3, IGFBP6, FOXO3, FZD1, INSR, MT1X, LDLR, IGFBP3

Catalytic activity

CYP24A1, CDKN3, DHFR, BRCA1, LIPC, AURKA, CDC2, MAOB, SCP2, CDK2, CDK6, BRCA2, ACAT1, CCNH, CDK4, CHEK1, AURKB, CDK5, IDE

SOD2, SOD3, INSR, DUSP5

Transcription regulator activity

RB1, BRCA1, BRCA2, E2F4, CDH1

FOXO3

Structural molecular activity

–

WNT6

Molecular transducer activity

FZD6, CDK5, IDE, FZD4

FZD7, FZD9, IRS2, FZD10, FZD8, WNT6, FZD1, INSR, MT1X, LDLR

Enzyme regulator activity

CDH1, CCNE1

IGFBP3

Transporter activity

LIPC, MTTP, APOB

LDLR

Electron carrier activity

CYP24A1, MAOB

–

Antioxidant activity

–

SOD3

Cell part

CYP24A1, LGR5, CDH2, RB1, CCNB1, CCNB2, E2F5, TYMS, BRCA1, LIPC, ATG4C, SOS1, AURKA, G2E3, CDC2, CHEK2, BRCC3, MAOB, MTTP, SCP2, GAS2, MTHFD1, CDK2, CCNA2, APOH, CKS1B, RBL1, UBE2C, FZD6, BARD1, PAK2, CDK6, RBL2, BRCA2, CCNF, ACAT1, CCNH, CDK4, PAK1IP1, NUCKS1, DKK1, STAT2, CHEK1, CCNE1, AURKB, CDK5, E2F4, DAPK1, IDE, TOP2B, BCCIP, CSNK1G3, APOB, CDH1, TET1, APOBEC3F, FZD4, ACAT2, CSNK1G2, CCNE2, CDK7, LRP1

FZD7, CTNNA2, CDK5R1, CDH4, APC2, FZD9, IRS2, CDKN2D, FZD10, CDKN1C, AQP6, SOD2, FOLR3, FZD8, AQP12A, SOD3, FOXO3, FZD1, CDKN2B, CDKN1A, LRP12, INSR, LDLR, AQP3, EGLN3, IGFBP3, DUSP5

Extracellular region

LIPC, ATG4C, APOH, DKK1, APOB

APC2, IGFBP2, IGF2, FOLR3, WNT6, SOD3, IGFBP6, IGFBP4, IGFBP1, IGFBP3

Synapse

CDH2, CDK5

CDK5R1

Extracellular region part

LIPC, APOH, IDE, APOB

APC2, IGFBP2, IGF2, WNT6, SOD3, IGFBP4, IGFBP1, IGFBP3

Macromolecular complex

–

APC2

Synapse part

SOS1

–