Genetic markers | Platelet (thousand/mm3) | Plateletocrit (%) | MPV (fl) | PDW (%) | ||||
---|---|---|---|---|---|---|---|---|
Before | After | Before | After | Before | After | Before | After | |
Hp | ||||||||
 1F-1F | 313.75 ± 13.54 | 277.38 ± 12.83*,≠| 0.31 ± 0.02 | 0.25 ± 0.01*,≠| 10.27 ± 0.60 | 9.18 ± 0.60 | 18.18 ± 0.49 | 17.63 ± 0.37 |
 1F-1S | 324.87 ± 25.18 | 280.88 ± 22.57*,≠| 0.34 ± 0.03 | 0.27 ± 0.03*,≠| 10.59 ± 0.40 | 9.67 ± 0.35 | 18.70 ± 0.38 | 17.6 ± 0.07 |
 1S-1S | 328.42 ± 20.64 | 306.05 ± 18.46 | 0.37 ± 0.03 | 0.32 ± 0.02*,a,≠| 11.52 ± 0.50 | 10.58 ± 0.33*,≠| 18.39 ± 0.31 | 18.19 ± 0.18 |
 1F-2 | 369.35 ± 17.74 | 339.90 ± 13.66*,≠| 0.37 ± 0.02 | 0.34 ± 0.02*,a | 10.06 ± 0.28*,b,c | 9.92 ± 0.32 | 17.55 ± 0.15 | 17.71 ± 0.22 |
 1S-2 | 332.31 ± 10.98 | 306.75 ± 11.57*,≠| 0.34 ± 0.01 | 0.31 ± 0.01*,a,≠| 10.10 ± 0.28*,c | 10.13 ± 0.29 | 17.83 ± 0.21 | 18.03 ± 0.20 |
 2-2 | 328.97 ± 10.19 | 320.37 ± 9.86 | 0.37 ± 0.02 | 0.36 ± 0.01*,a,b,e | 10.76 ± 0.27*,e | 11.18 ± 0.33**,a,*,b,d,e | 18.07 ± 0.23 | 18.58 ± 0.20**,b,d,*e,≠|
 P values | 0.451 | 0.099 | 0.566 | 0.002 | 0.056 | 0.023 | 0.140 | 0.027 |
MnSOD | ||||||||
 Val/Val | 352.26 ± 16.72 | 317.58 ± 14.90*,≠| 0.37 ± 0.02 | 0.32 ± 0.02 | 10.11 ± 0.35 | 9.94 ± 0.37 | 17.77 ± 0.24 | 17.92 ± 0.29 |
 Val/Ala | 332.88 ± 7.08 | 312.28 ± 6.66**,≠| 0.35 ± 0.01 | 0.33 ± 0.01**,≠| 10.60 ± 0.18 | 10.47 ± 0.18 | 18.03 ± 0.12 | 18.15 ± 0.11 |
 Ala/Ala | 316.00 ± 25.3 | 289.20 ± 27.99 | 0.41 ± 0.08 | 0.31 ± 0.03 | 10.95 ± 0.27 | 10.13 ± 0.54 | 18.48 ± 0.68 | 17.96 ± 0.22 |
 P values | 0.306 | 0.563 | 0.456 | 0.786 | 0.261 | 0.351 | 0.683 | 0.618 |
CAT | ||||||||
 AA | 347.59 ± 14.97 | 326.50 ± 15.01 | 0.35 ± 0.02 | 0.32 ± 0.02 | 10.03 ± 0.31 | 9.76 ± 0.28 | 17.78 ± 0.25 | 18.04 ± 0.22 |
 AT | 337.66 ± 9.52 | 318.64 ± 8.87 | 0.36 ± 0.01 | 0.34 ± 0.01 | 10.62 ± 0.23 | 10.67 ± 0.25 | 17.96 ± 0.15 | 18.19 ± 0.15 |
 TT | 326.96 ± 10.35 | 298.55 ± 9.11**,≠| 0.36 ± 0.02 | 0.31 ± 0.01**,≠| 10.68 ± 0.26 | 10.34 ± 0.26 | 18.17 ± 0.20 | 18.04 ± 0.16 |
 P values | 0.434 | 0.120 | 0.901 | 0.235 | 0.268 | 0.099 | 0.380 | 0.782 |
GPx-1 | ||||||||
 Pro/Pro | 348.84 ± 9.96 | 323.69 ± 9.34**,≠| 0.37 ± 0.01 | 0.33 ± 0.01**,≠| 10.51 ± 0.23 | 10.16 ± 0.19 | 17.99 ± 0.15 | 18.00 ± 0.12 |
 Pro/Leu | 321.1 ± 8.77 | 298.88 ± 8.23**,≠| 0.34 ± 0.01 | 0.32 ± 0.01*,≠| 10.62 ± 0.25 | 10.59 ± 0.28 | 18.11 ± 0.19 | 18.27 ± 0.17 |
 Leu/Leu | 327 ± 16.24 | 309.77 ± 14.69 | 0.34 ± 0.02 | 0.33 ± 0.02 | 10.31 ± 0.30 | 10.49 ± 0.48 | 17.68 ± 0.16 | 17.94 ± 0.35 |
 P values | 0.346 | 0.122 | 0.390 | 0.535 | 0.877 | 0.697 | 0.640 | 0.457 |
ACE | ||||||||
 DD | 320.05 ± 10.88 | 311.21 ± 11.45 | 0.34 ± 0.01 | 0.34 ± 0.02 | 10.80 ± 0.27 | 10.94 ± 0.31 | 18.04 ± 0.20 | 18.31 ± 0.18 |
 ID | 348.32 ± 9.08 | 313.42 ± 7.98**,≠| 0.37 ± 0.01 | 0.32 ± 0.01**,≠| 10.53 ± 0.21 | 10.04 ± 0.19* | 18.11 ± 0.15 | 18.00 ± 0.13 |
 II | 328.00 ± 13.67 | 310.22 ± 12.47 | 0.32 ± 0.02 | 0.32 ± 0.01 | 9.97 ± 0.38 | 10.22 ± 0.34 | 17.59 ± 0.24 | 18.02 ± 0.24 |
 P values | 0.189 | 0.948 | 0.081 | 0.525 | 0.132 | 0.082 | 0.237 | 0.621 |
GSTM1 | ||||||||
 Null | 335.19 ± 6.78 | 307.97 ± 6.60**,≠| 0.35 ± 0.01 | 0.32 ± 0.01**,≠| 10.31 ± 0.16 | 10.25 ± 0.19 | 17.94 ± 0.12 | 18.13 ± 0.12 |
 Non-null | 335.40 ± 13.09 | 319.83 ± 11.63 | 0.37 ± 0.02 | 0.34 ± 0.01*,≠| 10.97 ± 0.32 | 10.61 ± 0.27 | 18.14 ± 0.22 | 18.06 ± 0.18 |
 P values | 0.621 | 0.443 | 0.749 | 0.135 | 0.120 | 0.153 | 0.519 | 0.519 |
GSTT1 | ||||||||
 Null | 365.53 ± 16.58 | 329.41 ± 15.32**,≠| 0.40 ± 0.03 | 0.33 ± 0.02*,≠| 10.23 ± 0.43 | 9.86 ± 0.36 | 18.28 ± 0.37 | 17.79 ± 0.25 |
 Non-null | 330.23 ± 6.76 | 309.28 ± 6.40**,≠| 0.35 ± 0.01 | 0.32 ± 0.01**,≠| 10.59 ± 0.16 | 10.46 ± 0.17 | 17.96 ± 0.11 | 18.16 ± 0.11 |
 P values | 0.053 | 0.302 | 0.263 | 0.720 | 0.262 | 0.207 | 0.569 | 0.197 |
CK NcoI | ||||||||
 AA | 336.88 ± 9.25 | 315.88 ± 7.29**,≠| 0.35 ± 0.01 | 0.33 ± 0.01*,≠| 10.51 ± 0.22 | 10.29 ± 0.20 | 17.79 ± 0.16 | 18.02 ± 0.13 |
 AG | 332.96 ± 9.52 | 305.47 ± 9.91**,≠| 0.36 ± 0.01 | 0.32 ± 0.01**,≠| 10.55 ± 0.23 | 10.41 ± 0.26 | 18.23 ± 0.15*,a | 18.09 ± 0.15 |
 GG | 339.50 ± 19.06 | 334.00 ± 29.86 | 0.37 ± 0.03 | 0.37 ± 0.05 | 10.67 ± 0.49 | 10.92 ± 0.68 | 18.08 ± 0.50 | 18.98 ± 0.40 |
 P values | 0.932 | 0.728 | 0.822 | 0.321 | 0.888 | 0.668 | 0.045 | 0.103 |
CK TaqI | ||||||||
 1-1 | 370.91 ± 36.07 | 331.36 ± 24.45 | 0.40 ± 0.04 | 0.35 ± 0.03 | 10.29 ± 0.41 | 10.06 ± 0.30 | 17.72 ± 0.30 | 18.20 ± 0.18 |
 1-2 | 325.21 ± 7.91 | 304.90 ± 8.52**,≠| 0.34 ± 0.01 | 0.32 ± 0.01*,≠| 10.53 ± 0.23 | 10.44 ± 0.24 | 17.96 ± 0.16 | 18.03 ± 0.15 |
 2-2 | 339.10 ± 8.89 | 316.36 ± 8.51**,≠| 0.37 ± 0.01 | 0.33 ± 0.01**,≠| 10.59 ± 0.23 | 10.36 ± 0.24 | 18.12 ± 0.17 | 18.17 ± 0.15 |
 P values | 0.379 | 0.310 | 0.069 | 0.572 | 0.894 | 0.941 | 0.580 | 0.493 |
CRP G1059C | ||||||||
 GG | 332.34 ± 6.43 | 309.26 ± 6.31**,≠| 0.35 ± 0.01 | 0.32 ± 0.01**,≠| 10.54 ± 0.16 | 10.30 ± 0.15 | 18.03 ± 0.12 | 18.05 ± 0.10 |
 GC | 359.15 ± 24.70 | 335.77 ± 16.05 | 0.40 ± 0.04 | 0.37 ± 0.03 | 10.51 ± 0.39 | 10.98 ± 0.69 | 17.83 ± 0.31 | 18.50 ± 0.34 |
 P values | 0.380 | 0.180 | 0.211 | 0.056 | 0.819 | 0.431 | 0.601 | 0.151 |
MTHFR C677T | ||||||||
 CC | 324.63 ± 9.52 | 299.47 ± 8.47**,≠| 0.35 ± 0.01 | 0.31 ± 0.01**,≠| 10.73 ± 0.25 | 10.26 ± 0.23 | 18.18 ± 0.18 | 18.06 ± 0.14 |
 CT | 336.83 ± 9.21 | 323.74 ± 9.26**,a | 0.34 ± 0.01 | 0.33 ± 0.01 | 10.32 ± 0.21 | 10.30 ± 0.20 | 17.76 ± 0.13 | 18.01 ± 0.14 |
 TT | 370.80 ± 17.73**,a | 324.07 ± 16.81**,≠| 0.41 ± 0.03*,a | 0.36 ± 0.03*,a | 10.49 ± 0.39 | 11.12 ± 0.64 | 18.16 ± 0.34 | 18.59 ± 0.36 |
 P values | 0.016 | 0.015 | 0.066 | 0.047 | 0.627 | 0.435 | 0.312 | 0.359 |
MTHFR A1298C | ||||||||
 AA | 331.28 ± 8.32 | 312.60 ± 8.15**,≠| 0.35 ± 0.01 | 0.33 ± 0.01*,≠| 10.54 ± 0.20 | 10.52 ± 0.21 | 18.00 ± 0.14 | 18.15 ± 0.13 |
 AC | 343.09 ± 10.15 | 311.44 ± 8.73**,≠| 0.36 ± 0.01 | 0.32 ± 0.01**,≠| 10.58 ± 0.24 | 10.21 ± 0.23 | 18.04 ± 0.18 | 18.06 ± 0.14 |
 CC | 303.00 ± 6.00 | 312.50 ± 16.50 | 0.29 ± 0.04 | 0.30 ± 0.09 | 9.50 ± 1.20 | 9.30 ± 2.10 | 17.35 ± 0.45 | 17.60 ± 1.60 |
 P values | 0.539 | 0.980 | 0.227 | 0.748 | 0.643 | 0.525 | 0.686 | 0.808 |