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Table 5 Influences of Haptoglobin (Hp), MnSOD, CAT, GPx-1, ACE, GSTM1, GSTT1, CK NcoI, CK TaqI, CRP G1059C, MTHFR C677T and MTHFR A1298C genes’ polymorphisms on the plateletgram before and after pequi-oil supplementation

From: Genetic polymorphisms influence runners’ responses to the dietary ingestion of antioxidant supplementation based on pequi oil (Caryocar brasiliense Camb.): a before-after study

Genetic markers

Platelet (thousand/mm3)

Plateletocrit (%)

MPV (fl)

PDW (%)

Before

After

Before

After

Before

After

Before

After

Hp

 1F-1F

313.75 ± 13.54

277.38 ± 12.83*,≠

0.31 ± 0.02

0.25 ± 0.01*,≠

10.27 ± 0.60

9.18 ± 0.60

18.18 ± 0.49

17.63 ± 0.37

 1F-1S

324.87 ± 25.18

280.88 ± 22.57*,≠

0.34 ± 0.03

0.27 ± 0.03*,≠

10.59 ± 0.40

9.67 ± 0.35

18.70 ± 0.38

17.6 ± 0.07

 1S-1S

328.42 ± 20.64

306.05 ± 18.46

0.37 ± 0.03

0.32 ± 0.02*,a,≠

11.52 ± 0.50

10.58 ± 0.33*,≠

18.39 ± 0.31

18.19 ± 0.18

 1F-2

369.35 ± 17.74

339.90 ± 13.66*,≠

0.37 ± 0.02

0.34 ± 0.02*,a

10.06 ± 0.28*,b,c

9.92 ± 0.32

17.55 ± 0.15

17.71 ± 0.22

 1S-2

332.31 ± 10.98

306.75 ± 11.57*,≠

0.34 ± 0.01

0.31 ± 0.01*,a,≠

10.10 ± 0.28*,c

10.13 ± 0.29

17.83 ± 0.21

18.03 ± 0.20

 2-2

328.97 ± 10.19

320.37 ± 9.86

0.37 ± 0.02

0.36 ± 0.01*,a,b,e

10.76 ± 0.27*,e

11.18 ± 0.33**,a,*,b,d,e

18.07 ± 0.23

18.58 ± 0.20**,b,d,*e,≠

 P values

0.451

0.099

0.566

0.002

0.056

0.023

0.140

0.027

MnSOD

 Val/Val

352.26 ± 16.72

317.58 ± 14.90*,≠

0.37 ± 0.02

0.32 ± 0.02

10.11 ± 0.35

9.94 ± 0.37

17.77 ± 0.24

17.92 ± 0.29

 Val/Ala

332.88 ± 7.08

312.28 ± 6.66**,≠

0.35 ± 0.01

0.33 ± 0.01**,≠

10.60 ± 0.18

10.47 ± 0.18

18.03 ± 0.12

18.15 ± 0.11

 Ala/Ala

316.00 ± 25.3

289.20 ± 27.99

0.41 ± 0.08

0.31 ± 0.03

10.95 ± 0.27

10.13 ± 0.54

18.48 ± 0.68

17.96 ± 0.22

 P values

0.306

0.563

0.456

0.786

0.261

0.351

0.683

0.618

CAT

 AA

347.59 ± 14.97

326.50 ± 15.01

0.35 ± 0.02

0.32 ± 0.02

10.03 ± 0.31

9.76 ± 0.28

17.78 ± 0.25

18.04 ± 0.22

 AT

337.66 ± 9.52

318.64 ± 8.87

0.36 ± 0.01

0.34 ± 0.01

10.62 ± 0.23

10.67 ± 0.25

17.96 ± 0.15

18.19 ± 0.15

 TT

326.96 ± 10.35

298.55 ± 9.11**,≠

0.36 ± 0.02

0.31 ± 0.01**,≠

10.68 ± 0.26

10.34 ± 0.26

18.17 ± 0.20

18.04 ± 0.16

 P values

0.434

0.120

0.901

0.235

0.268

0.099

0.380

0.782

GPx-1

 Pro/Pro

348.84 ± 9.96

323.69 ± 9.34**,≠

0.37 ± 0.01

0.33 ± 0.01**,≠

10.51 ± 0.23

10.16 ± 0.19

17.99 ± 0.15

18.00 ± 0.12

 Pro/Leu

321.1 ± 8.77

298.88 ± 8.23**,≠

0.34 ± 0.01

0.32 ± 0.01*,≠

10.62 ± 0.25

10.59 ± 0.28

18.11 ± 0.19

18.27 ± 0.17

 Leu/Leu

327 ± 16.24

309.77 ± 14.69

0.34 ± 0.02

0.33 ± 0.02

10.31 ± 0.30

10.49 ± 0.48

17.68 ± 0.16

17.94 ± 0.35

 P values

0.346

0.122

0.390

0.535

0.877

0.697

0.640

0.457

ACE

 DD

320.05 ± 10.88

311.21 ± 11.45

0.34 ± 0.01

0.34 ± 0.02

10.80 ± 0.27

10.94 ± 0.31

18.04 ± 0.20

18.31 ± 0.18

 ID

348.32 ± 9.08

313.42 ± 7.98**,≠

0.37 ± 0.01

0.32 ± 0.01**,≠

10.53 ± 0.21

10.04 ± 0.19*

18.11 ± 0.15

18.00 ± 0.13

 II

328.00 ± 13.67

310.22 ± 12.47

0.32 ± 0.02

0.32 ± 0.01

9.97 ± 0.38

10.22 ± 0.34

17.59 ± 0.24

18.02 ± 0.24

 P values

0.189

0.948

0.081

0.525

0.132

0.082

0.237

0.621

GSTM1

 Null

335.19 ± 6.78

307.97 ± 6.60**,≠

0.35 ± 0.01

0.32 ± 0.01**,≠

10.31 ± 0.16

10.25 ± 0.19

17.94 ± 0.12

18.13 ± 0.12

 Non-null

335.40 ± 13.09

319.83 ± 11.63

0.37 ± 0.02

0.34 ± 0.01*,≠

10.97 ± 0.32

10.61 ± 0.27

18.14 ± 0.22

18.06 ± 0.18

 P values

0.621

0.443

0.749

0.135

0.120

0.153

0.519

0.519

GSTT1

 Null

365.53 ± 16.58

329.41 ± 15.32**,≠

0.40 ± 0.03

0.33 ± 0.02*,≠

10.23 ± 0.43

9.86 ± 0.36

18.28 ± 0.37

17.79 ± 0.25

 Non-null

330.23 ± 6.76

309.28 ± 6.40**,≠

0.35 ± 0.01

0.32 ± 0.01**,≠

10.59 ± 0.16

10.46 ± 0.17

17.96 ± 0.11

18.16 ± 0.11

 P values

0.053

0.302

0.263

0.720

0.262

0.207

0.569

0.197

CK NcoI

 AA

336.88 ± 9.25

315.88 ± 7.29**,≠

0.35 ± 0.01

0.33 ± 0.01*,≠

10.51 ± 0.22

10.29 ± 0.20

17.79 ± 0.16

18.02 ± 0.13

 AG

332.96 ± 9.52

305.47 ± 9.91**,≠

0.36 ± 0.01

0.32 ± 0.01**,≠

10.55 ± 0.23

10.41 ± 0.26

18.23 ± 0.15*,a

18.09 ± 0.15

 GG

339.50 ± 19.06

334.00 ± 29.86

0.37 ± 0.03

0.37 ± 0.05

10.67 ± 0.49

10.92 ± 0.68

18.08 ± 0.50

18.98 ± 0.40

 P values

0.932

0.728

0.822

0.321

0.888

0.668

0.045

0.103

CK TaqI

 1-1

370.91 ± 36.07

331.36 ± 24.45

0.40 ± 0.04

0.35 ± 0.03

10.29 ± 0.41

10.06 ± 0.30

17.72 ± 0.30

18.20 ± 0.18

 1-2

325.21 ± 7.91

304.90 ± 8.52**,≠

0.34 ± 0.01

0.32 ± 0.01*,≠

10.53 ± 0.23

10.44 ± 0.24

17.96 ± 0.16

18.03 ± 0.15

 2-2

339.10 ± 8.89

316.36 ± 8.51**,≠

0.37 ± 0.01

0.33 ± 0.01**,≠

10.59 ± 0.23

10.36 ± 0.24

18.12 ± 0.17

18.17 ± 0.15

 P values

0.379

0.310

0.069

0.572

0.894

0.941

0.580

0.493

CRP G1059C

 GG

332.34 ± 6.43

309.26 ± 6.31**,≠

0.35 ± 0.01

0.32 ± 0.01**,≠

10.54 ± 0.16

10.30 ± 0.15

18.03 ± 0.12

18.05 ± 0.10

 GC

359.15 ± 24.70

335.77 ± 16.05

0.40 ± 0.04

0.37 ± 0.03

10.51 ± 0.39

10.98 ± 0.69

17.83 ± 0.31

18.50 ± 0.34

 P values

0.380

0.180

0.211

0.056

0.819

0.431

0.601

0.151

MTHFR C677T

 CC

324.63 ± 9.52

299.47 ± 8.47**,≠

0.35 ± 0.01

0.31 ± 0.01**,≠

10.73 ± 0.25

10.26 ± 0.23

18.18 ± 0.18

18.06 ± 0.14

 CT

336.83 ± 9.21

323.74 ± 9.26**,a

0.34 ± 0.01

0.33 ± 0.01

10.32 ± 0.21

10.30 ± 0.20

17.76 ± 0.13

18.01 ± 0.14

 TT

370.80 ± 17.73**,a

324.07 ± 16.81**,≠

0.41 ± 0.03*,a

0.36 ± 0.03*,a

10.49 ± 0.39

11.12 ± 0.64

18.16 ± 0.34

18.59 ± 0.36

 P values

0.016

0.015

0.066

0.047

0.627

0.435

0.312

0.359

MTHFR A1298C

 AA

331.28 ± 8.32

312.60 ± 8.15**,≠

0.35 ± 0.01

0.33 ± 0.01*,≠

10.54 ± 0.20

10.52 ± 0.21

18.00 ± 0.14

18.15 ± 0.13

 AC

343.09 ± 10.15

311.44 ± 8.73**,≠

0.36 ± 0.01

0.32 ± 0.01**,≠

10.58 ± 0.24

10.21 ± 0.23

18.04 ± 0.18

18.06 ± 0.14

 CC

303.00 ± 6.00

312.50 ± 16.50

0.29 ± 0.04

0.30 ± 0.09

9.50 ± 1.20

9.30 ± 2.10

17.35 ± 0.45

17.60 ± 1.60

 P values

0.539

0.980

0.227

0.748

0.643

0.525

0.686

0.808

  1. Data are expressed as mean ± SEM (standard error of mean) MPV mean platelet volume, PDW platelet deviation weight, fl femtoliters. For GSTM1, GSTT1, and CRP G1059C, P values were generated by the Mann–Whitney U test; for the other genetic markers, P values were generated by the Kruskall–Wallis test. The lower case letters indicate differences between two specific genotypes detected by the Mann–Whitney U test. Asterisks indicate significant (* P < 0.05) and highly significant (** P < 0.01) differences. The lower case letters indicate significant differences between two specific genotypes, with a = significant compared with the first genotype of each genetic marker; b = significant compared with the second genotype of each genetic marker; c = significant compared with the third genotype of each genetic marker. For Hp polymorphism, the lower case letters d, e, and f were also added, with d = significant compared with 1F-2; e = significant compared with 1S-2; and f = significant compared to 2-2 genotypes. The symbol ≠ indicates significant differences in the comparison of before-after pequi-oil supplementation detected by the Wilcoxon matched pairs test