Genetic polymorphisms influence runners’ responses to the dietary ingestion of antioxidant supplementation based on pequi oil (Caryocar brasiliense Camb.): a before-after study

Miranda-Vilela, Ana Luisa; Lordelo, Graciana Souza; Akimoto, Arthur Kenji; Alves, Penha Cristina Zaidan; Pereira, Luiz Carlos da Silva; Klautau-Guimarães, Maria de Nazaré; Grisolia, Cesar Koppe

doi:10.1007/s12263-011-0217-y

Table 6 Influences of Haptoglobin (Hp), MnSOD, CAT, GPx-1, ACE, GSTM1, GSTT1, CK NcoI, CK TaqI, CRP G1059C, MTHFR C677T, and MTHFR A1298C genes’ polymorphisms on the postprandial lipid profile before and after pequi-oil supplementation

From: Genetic polymorphisms influence runners’ responses to the dietary ingestion of antioxidant supplementation based on pequi oil (Caryocar brasiliense Camb.): a before-after study

Genetic markers	Total cholesterol (mg/dL)		Triglycerides (mg/dL)		HDL (mg/dL)		LDL (mg/dL)		VLDL (mg/dL)
Genetic markers	Before	After	Before	After	Before	After	Before	After	Before	After
Hp
1F-1F	192.37 ± 13.88	186.88 ± 8.54	165.38 ± 36.12	137.50 ± 20.71	55.50 ± 4.14	59.38 ± 4.42*^,≠	103.80 ± 12.99	100.00 ± 7.12	33.08 ± 7.22	27.50 ± 4.14
1F-1S	184.88 ± 9.42	187.75 ± 9.92	106.88 ± 21.20	111.50 ± 18.72	54.00 ± 3.89	55.13 ± 3.73	109.50 ± 7.75	110.33 ± 8.29	21.38 ± 4.24	22.30 ± 3.74
1S-1S	178.50 ± 11.91	176.06 ± 10.57	116.33 ± 11.69	128.50 ± 16.56	45.94 ± 3.63	46.61 ± 3.84	109.29 ± 11.21	103.74 ± 9.08	23.27 ± 2.34	25.70 ± 3.31
1F-2	190.3 ± 8.71	190.45 ± 7.70	98.26 ± 9.77	117.32 ± 12.37*^,≠	52.85 ± 2.81	51.50 ± 2.82	115.93 ± 6.44	113.64 ± 6.42	19.65 ± 1.95	23.46 ± 2.47*^,≠
1S-2	186.28 ± 6.60	182.87 ± 6.07	104.44 ± 7,62	115.63 ± 8.17	54.61 ± 1.57	53.21 ± 1.81	111.24 ± 5.69	106.53 ± 5.44	20.89 ± 1.52	23.13 ± 1.63
2-2	192.36 ± 6.27	195.76 ± 5.91	117.09 ± 12.67	112.76 ± 8.08	59.03 ± 2.67* ^,c	60.48 ± 2.61*,^c,^e	110.33 ± 4.34	112.49 ± 4.16	23.42 ± 2.53	22.55 ± 1.62
P values	0.881	0.495	0.562	0.889	0.166	0.011	0.882	0.511	0.562	0.889
MnSOD
Val/Val	196.05 ± 7.93	193.00 ± 7.95	115.32 ± 14.99	100.53 ± 8.22	57.05 ± 3.96	56.11 ± 3.74	115.94 ± 6.49	116.79 ± 6.53	23.06 ± 3.00	20.11 ± 1.64
Val/Ala	185.41 ± 4.08	186.27 ± 3.69	111.29 ± 5.75	122.62 ± 5.55* ^,≠	53.31 ± 1.30	53.92 ± 1.41	109.72 ± 3.48	107.23 ± 3.05	22.26 ± 1.15	24.53 ± 1.11
Ala/Ala	198.67 ± 13.73	185.17 ± 10.96* ^,≠	134.00 ± 47.03	106.83 ± 29.81	60.33 ± 2.54	58.17 ± 1.70	111.53 ± 5.36	105.63 ± 4.98	26.80 ± 9.41	21.37 ± 5.96
P values	0.429	0.742	1.000	0.130	0.130	0.390	0.560	0.330	1.000	0.130
CAT
AA	184.41 ± 7.79	187.82 ± 6.81	98.68 ± 11.13	128.27 ± 14.16*,^≠	49.27 ± 2.67	48.41 ± 2.35	116.30 ± 7.64	113.45 ± 7.18	19.74 ± 2.23	25.66 ± 2.83*,^≠
AT	189.86 ± 5.95	188.61 ± 4.85	120.74 ± 10.21	117.44 ± 7.26	55.53 ± 1.80	56.45 ± 2.03	109.41 ± 4.69	107.83 ± 3.72	24.15 ± 2.04	23.49 ± 1.45
TT	187.09 ± 5.23	185.57 ± 5.54	111.67 ± 7.26	114.37 ± 6.84	55.19 ± 2.02	55.17 ± 2.01	109.86 ± 4.28	107.47 ± 4.32	22.34 ± 1.45	22.87 ± 1.37
P values	0.849	0.912	0.383	0.956	0.274	0.117	0.886	0.868	0.383	0.956
GPx-1
Pro/Pro	187.14 ± 5.09	190.45 ± 4.66	117.12 ± 8.60	119.63 ± 6.71	54.76 ± 1.93	56.49 ± 1.91* ^,≠	108.70 ± 4.10	109.07 ± 3.65	23.43 ± 1.72	23.93 ± 1.34
Pro/Leu	189.09 ± 5.55	183.55 ± 5.22	106.34 ± 6.61	117.81 ± 8.29	53.28 ± 1.85	51.68 ± 1.99	114.54 ± 5.07	108.31 ± 4.60*^,≠	21.27 ± 1.32	23.56 ± 1.66
Leu/Leu	186.07 ± 11.21	186.71 ± 8.59	119.36 ± 22.86	114.21 ± 12.62	55.36 ± 2.07	55.36 ± 2.54	106.84 ± 6.90	108.51 ± 6.55	23.87 ± 4.57	22.84 ± 2.52
P values	0.953	0.608	0.948	0.790	0.828	0.363	0.810	0.787	0.948	0.790
ACE
DD	178.44 ± 5.97	178.41 ± 5.01	107.71 ± 10.01	116.83 ± 8.20	54.43 ± 2.20	55.21 ± 2.21	102.98 ± 3.95	99.27 ± 3.65	21.54 ± 2.00	23.37 ± 1.64
ID	197.22 ± 5.01*,^a	194.86 ± 4.78	116.26 ± 8.11	119.90 ± 7.29	54.64 ± 1.75	54.81 ± 1.90	118.80 ± 4.65* ^,a	115.49 ± 4.12**,^a	23.25 ± 1.62	23.98 ± 1.46
II	178.63 ± 7.80	182.89 ± 7.46	115.05 ± 11.59	116.37 ± 10.19	52.63 ± 2.49	51.79 ± 2.35	102.99 ± 6.39	107.83 ± 5.80	23.01 ± 2.32	23.27 ± 2.04
P values	0.029	0.057	0.461	0.911	0.880	0.779	0.047	0.024	0.461	0.911
GSTM1
Null	192.33 ± 4.50	190.22 ± 4.00	110.27 ± 7.04	114.19 ± 5.77	55.14 ± 1.60	55.37 ± 1.61	114.67 ± 3.78	111.50 ± 3.31	22.06 ± 1.41	22.84 ± 1.15
Non-null	179.12 ± 5.47	181.71 ± 5.37	118.39 ± 9.15	125.90 ± 8.66	52.60 ± 1.78	52.81 ± 2.01	103.42 ± 4.39	103.31 ± 4.30	23.68 ± 1.83	25.18 ± 1.73
P values	0.076	0.210	0.291	0.224	0.194	0.239	0.065	0.205	0.291	0.224
GSTT1
Null	193.25 ± 6.89	189.44 ± 6.83	145.12 ± 16.9	143.81 ± 14.92	52.88 ± 3.20	53.63 ± 4.09	111.35 ± 6.65	107.05 ± 5.22	29.03 ± 3.38	28.76 ± 2.98
Non-null	186.93 ± 3.94	186.95 ± 3.57	108.07 ± 5.76*,^a	114.25 ± 4.99* ^,a	54.46 ± 1.32	54.61 ± 1.32	110.74 ± 3.25	108.96 ± 2.95	21.61 ± 1.15* ^,a	22.85 ± 1.00* ^,a
P values	0.544	0.793	0.017	0.031	0.988	0.616	0.824	0.956	0.017	0.031
CK NcoI
AA	189.62 ± 4.32	184.72 ± 4.19	118.90 ± 8.20	113.75 ± 6.33	52.49 ± 1.45	51.52 ± 1.52	113.62 ± 4.05	110.47 ± 3.88	23.78 ± 1.64	22.75 ± 1.27
AG	186.58 ± 6.11	189.60 ± 5.32	107.69 ± 7.99	121.71 ± 7.59	56.28 ± 2.07	57.72 ± 2.13	108.17 ± 4.66	106.47 ± 3.86	21.54 ± 1.60	24.34 ± 1.52
GG	180.00 ± 14.11	192.50 ± 12.08	101.83 ± 24.04	133.50 ± 28.11* ^,≠	54.17 ± 6.06	55.83 ± 5.26	105.47 ± 9.75	109.97 ± 9.97	20.37 ± 4.81	26.70 ± 5.62* ^,≠
P values	0.809	0.713	0.543	0.618	0.406	0.067	0.624	0.979	0.543	0.618
CK TaqI
1-1	198.00 ± 7.70	191.17 ± 9.04	129.50 ± 21.22	123.50 ± 12.82	55.58 ± 4.47	53.42 ± 4.48	116.52 ± 8.09	113.05 ± 8.07	25.90 ± 4.24	24.70 ± 2.56
1-2	185.04 ± 5.46	184.30 ± 4.64	106.27 ± 7.46	115.00 ± 6.61	54.00 ± 1.94	53.98 ± 1.99	110.30 ± 4.66	107.07 ± 3.67	21.25 ± 1.49	23.00 ± 1.32
2-2	188.39 ± 5.39	189.65 ± 5.13	116.80 ± 8.84	120.66 ± 8.19	54.22 ± 1.58	55.27 ± 1.71	110.04 ± 4.22	109.45 ± 4.32	23.36 ± 1.77	24.13 ± 1.64
P values	0.570	0.680	0.327	0.701	0.942	0.857	0.680	0.732	0.327	0.701
CRP G1059C
GG	186.33 ± 3.72	185.17 ± 3.40	113.89 ± 6.04	117.83 ± 5.00	54.02 ± 1.29	54.00 ± 1.35	109.41 ± 3.11	107.06 ± 2.79	22.78 ± 1.21	23.57 ± 1.00
GC	199.62 ± 11.08	204.54 ± 8.89	106.69 ± 14.05	121.77 ± 17.61	56.15 ± 3.73	58.38 ± 3.64	122.12 ± 8.59	121.80 ± 7.61	21.34 ± 2.81	24.35 ± 3.52
P values	0.243	0.060	0.973	0.867	0.518	0.145	0.146	0.055	0.973	0.867
MTHFR C677T
CC	187.31 ± 5.20	185.64 ± 4.71	110.75 ± 8.18	116.51 ± 7.38	52.89 ± 1.60	53.11 ± 1.72	112.86 ± 4.80	109.02 ± 4.02	22.15 ± 1.64	23.30 ± 1.48
CT	187.98 ± 5.79	190.12 ± 5.10	115.00 ± 8.77	121.15 ± 7.56	56.08 ± 2.09	56.19 ± 2.24	108.02 ± 4.28	108.86 ± 4.15	23.00 ± 1.75	24.23 ± 1.51
TT	188.81 ± 9.02	184.44 ± 9.16	115.56 ± 16.26	115.81 ± 12.19	53.50 ± 3.56	54.13 ± 2.98	112.20 ± 6.79	107.15 ± 6.83	23.11 ± 3.25	23.16 ± 2.44
P values	0.990	0.766	0.858	0.773	0.653	0.767	0.735	0.980	0.858	0.773
MTHFR A1298C
AA	189.15 ± 4.69	187.17 ± 4.14	119.32 ± 7.84	125.41 ± 6.55	55.85 ± 1.54	55.51 ± 1.56	109.07 ± 3.62	105.95 ± 3.28	23.87 ± 1.57	25.08 ± 1.31
AC	185.27 ± 5.60	187.00 ± 5.38	102.51 ± 7.63	103.42 ± 6.36* ^,a,c	52.07 ± 2.01	53.20 ± 2.22	113.06 ± 5.19	112.96 ± 4.58	20.50 ± 1.53	20.68 ± 1.27* ^,a,c
CC	195.00 ± 16.00	198.00 ± 9.00	130.00 ± 2.00	198.50 ± 30.50	45.00 ± 3.00	45.50 ± 2.50	124.00 ± 12.60	112.80 ± 12.60	26.00 ± 0.40	39.70 ± 6.10
P values	0.841	0.911	0.212	0.010	0.181	0.265	0.641	0.659	0.212	0.010

Data are expressed as mean ± SEM (standard error of mean). For GSTM1, GSTT1 and CRP G1059C, P values were generated by the independent samples t-Test (total cholesterol) or Mann–Whitney U test (other variables); for the other genetic markers, P values were generated by ANOVA (total cholesterol) or by the Kruskall–Wallis test (other variables). Asterisks indicate significant (* P < 0.05) and highly significant (** P < 0.01) differences. The lower case letters indicate significant differences between two specific genotypes, with a = significant compared with the first genotype of each genetic marker; b = significant compared with the second genotype of each genetic marker; c = significant compared with the third genotype of each genetic marker. For Hp polymorphism, the lower case letters d, e, and f were also added, with d = significant compared with 1F-2; e = significant compared with 1S-2; and f = significant compared with 2-2 genotypes. The symbol ≠ indicates significant differences in the comparison of before-after pequi-oil supplementation detected by the Wilcoxon matched pairs test

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