Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E

Genes & Nutrition

Table 3 Effect of T3 molecules on cell viability of non-mammary cancer cell lines

T3 form	Non-mammary cancer cells	IC50[μM] (time of treatments)	References
δ-T3	MIA-PaCa^a	28^h (48 h)	(Hussein and Mo 2009)
	PANC-1^b	35^h (48 h)
	BxPC3^c	35^h (48 h)
	PC3^d	32^h (24 h)	(Yu et al. 1999) (Srivastava and Gupta 2006) (Kumar et al. 2006) Recenty reviewed in (Constantinou et al. 2009)
	PC3^d	25^h (48 h)
	DU 145^e	20^h (24 h)
	DU 145^e	27^h (48 h)
	LNCap^g	26^h (24 h)
	LNCap^g	19^h (48 h)
γ-T3	SGC 7901^f	27^h (72 h)	(Sun et al. 2008)
	PC3^d	33^h (24 h)	(Yu et al. 1999) (Srivastava and Gupta 2006) (Kumar et al. 2006) Recenty reviewed in (Constantinou et al. 2009)
	PC3^d	24^h (48 h)
	DU 145^e	34^h (24 h)
	DU 145^e	30^h (48 h)
	LNCap^g	21^h (24 h)
	LNCap^g	21^h (48 h)
α-T3	PC3^d	>100^h (24 h)
	PC3^d	>100^h (48 h)
	DU 145^e	>100^h (24 h)
	DU 145^e	>100^h (48 h)
	LNCap^g	>100^h (24 h)
	LNCap^g	>100^h (48 h)
β-T3	PC3^d	59^h (24 h)
	PC3^d	48^h (48 h)
	DU 145^e	60^h (24 h)
	DU 145^e	53^h (48 h)
	LNCap^g	70^h (24 h)
	LNCap^g	52^h (48 h)

^a MIA-PaCa human pancreatic cancer cell line
^b PANC1 human pancreatic cancer cell line
^c BxPC3 human ductal pancreatic adenocarcinoma cell line, derived from a 61-year-old women with a primary adenocarcinoma of the pancreas. These cells produce mucin and the tumor produced in nude mice is moderately well to poorly differentiated, thus suggesting close similarity to primary adenocarcinoma cells
^d PC3 androgen-independent human prostate adenocarcinoma cells
^e DU145 epithelial-like human androgen-independent prostate carcinoma
^f SGC 7901 human gastric carcinoma cells
^g LNCap androgen sensitive human prostate cancer cells
^hInhibition of viability assessed by MTT test or equivalent test

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