Table 2 Total and stratified analysis of two polymorphisms in RNASEL gene on prostate cancer
Variables | N | Case/control | M versus W | MM versus WW | MM + MW versus WW | |||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P h | OR (95% CI) | P h | OR (95% CI) | P h | |||
R462Q | ||||||||
Total | 13 | 8,019/7,632 | 1.00 (0.97–1.03) | 0.322 | 1.02 (0.94–1.10) | 0.217 | 0.99 (0.96–1.02) | 0.932 |
Race | ||||||||
Caucasian | 8 | 6,384/5,267 | 0.99 (0.96–1.03) | 0.733 | 0.99 (0.90–1.08) | 0.643 | 0.99 (0.96–1.02) | 0.912 |
African | 4 | 639/1,273 | 1.10 (0.92–1.32) | 0.056 | 2.50 (1.28–4.87) | 0.231 | 1.03 (0.86–1.22) | 0.433 |
Mixed | 1 | 996/1,092 | 1.01 (0.89–1.16) | – | 1.07 (0.80–1.43) | – | 0.99 (0.84–1.18) | – |
Source of case | ||||||||
Sporadic | 7 | 3,895/4,122 | 1.01 (0.97–1.05) | 0.945 | 1.04 (0.92–1.16) | 0.923 | 1.00 (0.97–1.04) | 0.824 |
Familial | 8 | 1,877/2,791 | 0.99 (0.84–1.17) | 0.007 | 1.03 (0.69–1.56) | 0.002 | 0.97 (0.92–1.02) | 0.315 |
Variables | N | Case/control | M versus W | MW versus WW | MM + MW versus WW | |||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P h | OR (95% CI) | P h | OR (95% CI) | P h | |||
D541E | ||||||||
Total | 13 | 5,353/4,321 | 1.04 (1.01–1.07) | 0.164 | 1.07 (1.02–1.13) | 0.059 | 1.02 (1.00–1.05) | 0.065 |
Race | ||||||||
Caucasian | 9 | 4,711/3,316 | 1.04 (1.01–1.07) | 0.828 | 1.07 (1.01–1.13) | 0.742 | 1.03 (1.00–1.05) | 0.396 |
African | 3 | 541/900 | 1.13 (1.01–1.26) | 0.458 | 1.49 (1.11–2.00) | 0.433 | 1.06 (0.96–1.17) | 0.699 |
Asian | 1 | 101/105 | 0.60 (0.39–0.92) | – | 0.14 (0.04–0.52) | – | 0.14 (0.04–0.48) | – |
Source of case | ||||||||
Sporadic | 6 | 2,305/2,148 | 1.24 (0.87–1.76) | 0.000 | 1.09 (1.04–1.15) | 0.078 | 1.43 (0.97–2.10) | 0.000 |
Familial | 10 | 1,864/3,012 | 1.27 (0.98–1.65) | 0.000 | 1.01 (0.72–1.42) | 0.000 | 1.18 (0.83–1.68) | 0.000 |