Fig. 3
From Wali et al. (2009a) with permission. Effects of mevalonate supplementation on the growth of +SA mammary tumor cells. Cells were plated at a density of 5 × 104 cells/well (6 wells/group) in 24-well culture plates and exposed to control (C), 0.25 μM simvastatin (S), 0.25 μM lovastatin (L), 0.25 μM mevastatin (M), 10 μM pravastatin (P), 2 μM γ-tocotrienol (T), 1 μM mevalonate (m1), or 2 μM mevalonate (m2) alone or combination with individual statins (S, L, M or P) and/or γ-tocotrienol (T) for a 4-day culture period. Afterward, viable cell count was determined using the MTT assay. Vertical bars indicate the mean cell count ±SEM in each treatment group. *P < 0.05 as compared with respective combination statin and γ-tocotrienol treatment groups not exposed mevalonate supplementation