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Table 1 Antibiotic resistance genes most commonly found in LAB

From: Antibiotic resistance determinants in the interplay between food and gut microbiota

Antibiotic (pharmacological class)

Resistance gene(s)

Mechanism of action

References

Tetracycline

(Tetracyclines)

tet(M), (S), (O), (W), (36)

Ribosomal protection

(Roberts 2005); (Thaker et al. 2010)

tet(L)

Efflux

(Roberts 2005); (Thaker et al. 2010)

tet(K)

Efflux

(Roberts 2005); (Thaker et al. 2010)

Erythromycin

(Macrolides)

erm(A), (B), (C), (F), (G)

rRNA Methylases

(Roberts 2008); (Mayrhofer et al. 2010)

msr(A/B), (D)

Efflux

(Roberts 2008); (Toomey et al. 2010)

isa(A)

Efflux

(Roberts 2008)

vga(B)

Efflux

(Roberts 2008)

Vancomycina

(Glycopepdtides)

van(A), (B), (D), (E), (G), (L)b

Peptidoglycan modification

(Werner et al. 2008)

van(C)c

Peptidoglycan modification

(Werner et al. 2008)

  1. aSome LAB genera (Lactobacillus, Pediococcus, Leuconostoc) are intrinsically resistant to Vancomycin
  2. bAcquired
  3. cIntrinsic