An oat bran meal influences blood insulin levels and related gene sets in peripheral blood mononuclear cells of healthy subjects

Table 2 The 16 most differentially expressed genes (P < 0.01) after oat bran or control meal intake (compared to before intake), as analysed by the Meal Intake Model

Gene name	Probe set identifier	Gene symbol	Oat bran meal			Control meal
Gene name	Probe set identifier	Gene symbol	Fold change	SEM	P-value	Fold change	SEM	P-value
Down-regulated
Pyruvat dehydrogenase kinase, isozyme 4	225207_at	PDK4	0.27	0.07	0.0005	0.22	0.04	<0.0001
DNA-damage-inducible transcript 4	202887_s_at	DDIT4	0.53	0.05	0.0001	0.45	0.05	0.0001
Transmembrane protein with EGF-like and two follistatin-like domains 2	224321_at	TMEFF2	0.54	0.06	0.0005	0.85	0.07	0.0955
Solute carrier family 16, member 10 (aromatic amino acid transporter)	219915_s_at	SLC16A10	0.59	0.07	0.0014	0.85	0.09	0.1543
Desmocollin 1	NuGO_eht0257197_at	DSC1	0.59	0.04	0.0001	0.77	0.08	0.0269
Aldo–keto reductase family 1, member C3	209160_at	AKR1C3	0.62	0.08	0.0063	0.56	0.05	0.0002
Chemokine (C–C motif) ligand 4	204103_at	CCL4	0.72	0.06	0.0033	0.56	0.03	<0.0001
Fasciculation and elongation protein zeta 1 (zygin I)	203562_at	FEZ1	0.73	0.07	0.0105	0.55	0.05	0.0002
Up-regulated
Early growth response protein 1	201694_s_at	EGR1	3.08	0.92	0.0046	2.37	1.36	0.1698
Neutrophil defensin 3 precursor	205033_s_at	DEFA3	2.07	1.16	0.2260	2.36	0.52	0.0036
Chemokine (C-X-C motif) ligand 16	223454_at	CXCL16	1.99	0.24	0.0003	1.44	0.15	0.0060
Cysteine-rich secretory protein LCCL domain containing 2	221541_at	CRISPLD2	1.95	0.14	<0.0001	1.79	0.20	0.0006
Carboxypeptidase M	206100_at	CPM	1.95	0.27	0.0010	1.23	0.14	0.0969
Caldesmon 1	212077_at	CALD1	1.91	0.16	<0.0001	1.27	0.10	0.0127
Lipocalin 2	212531_at	LCN2	1.80	0.19	0.0004	1.80	0.28	0.0040
G protein-coupled receptor 34	223620_at	GPR34	1.75	0.24	0.0024	2.08	0.12	<0.0001

Fold change and P-value for the other meal is shown for comparison. The genes are sorted according to fold change by the oat bran meal. (Mean values with their standard errors, n = 10)

ISSN: 1865-3499