An oat bran meal influences blood insulin levels and related gene sets in peripheral blood mononuclear cells of healthy subjects

Table 4 The 30 most significantly affected gene sets as a response to meal intake (after meal compared with before meal) of the total of 24 significantly down-regulated and 192 significantly up-regulated gene sets (P < 0.01, FDR q < 0.01) analysed with GSEA

Gene sets	FDR q-value	Gene set size
Down-regulated
REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS	<0.0001	78
KEGG_RIBOSOME	<0.0001	75
REACTOME_FORMATION_OF_A_POOL_OF_FREE_40S_SUBUNITS	<0.0001	73
REACTOME_VIRAL_MRNA_TRANSLATION	<0.0001	73
REACTOME_GTP_HYDROLYSIS_AND_JOINING_OF_THE_60S_RIBOSOMAL_SUBUNIT	<0.0001	82
REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	<0.0001	83
REACTOME_PEPTIDE_CHAIN_ELONGATION	<0.0001	74
HAHTOLA_SEZARY_SYNDROM_DN	<0.0001	34
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_DN	<0.0001	97
REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION	<0.0001	88
REACTOME_INFLUENZA_LIFE_CYCLE	<0.0001	120
REACTOME_TRANSLATION	<0.0001	95
REACTOME_GENE_EXPRESSION	<0.0001	329
JISON_SICKLE_CELL_DISEASE_DN	<0.0001	145
REACTOME_INSULIN_SYNTHESIS_AND_SECRETION	<0.0001	110
Up-regulated
VERHAAK_AML_WITH_NPM1_MUTATED_UP	<0.0001	159
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN	<0.0001	272
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN	<0.0001	193
RAGHAVACHARI_PLATELET_SPECIFIC_GENES	<0.0001	62
MCLACHLAN_DENTAL_CARIES_UP	<0.0001	187
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN	<0.0001	163
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP	<0.0001	347
SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP	<0.0001	141
JISON_SICKLE_CELL_DISEASE_UP	<0.0001	161
MCLACHLAN_DENTAL_CARIES_DN	<0.0001	210
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP	<0.0001	58
VALK_AML_CLUSTER_5	<0.0001	27
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN	<0.0001	372
GAL_LEUKEMIC_STEM_CELL_DN	<0.0001	207
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN	<0.0001	63

ISSN: 1865-3499