Fig. 4
From: Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells
VES modulates the cell cycle in PANC-1 and COLO-357 cells. a PANC-1 cells were treated with 80 μM VES at 48 h; VES induced modest G2/M arrest as shown in the cell cycle accompanied by downregulation of CDC-2 after 48 h (P < 0.05). b COLO-357 cells were treated with 80 μM VES for 24 h; there was no change in cell cycle. P < 0.05 was considered significant. Asterisk denotes P < 0.01 as compared to control. Expression of p21cip1/waf1, anti-p53, and antiphospho p53-Ser15 was determined by immunoblotting