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Fig. 1 | Genes & Nutrition

Fig. 1

From: Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations

Fig. 1

The effects of benfotiamine on a [U-14C]glucose oxidation (CO2 formation), b total metabolized glucose (sum of CO2 formation and cell-associated glucose) and c fractional oxidation of [U-14C]glucose (CO2/sum of cell-associated plus CO2) under NG (normoglycemic, 5.5 mM glucose) and HG (hyperglycemic, 20 mM glucose) conditions. Myotubes were treated for 4 days in the absence or presence of benfotiamine (100 and 200 μM) under NG and HG conditions. All data are normalized to normoglycemic control and presented as mean ± SEM (n = 5 for NG and n = 3 for HG, independent muscle cell donors). a P < 0.05 versus control myotubes not exposed to benfotiamine under NG conditions; b P < 0.05 versus control myotubes not exposed to benfotiamine under HG conditions (linear mixed model (LMM), SPSS). HG treatment significantly decreased glucose oxidation and total metabolized glucose (P < 0.001 overall effect) (LMM). d Dose–response effects of benfotiamine on [U-14C]glucose oxidation (CO2 formation) under NG conditions (mean ± SEM, n = 2)

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