Table 1 Unadjusted geometric mean concentrations of urinary biomarkers of oxidative stress according to study characteristics
Characteristics | 8-isoprostane F2α (pg/ml) n = 87 | 8-oxo-7,8-dihydro-2′-deoxyguanosine (pmol/ml) n = 93 | ||||
|---|---|---|---|---|---|---|
n | Mean (95% CI) | P-valuea | n | Mean (95% CI) | P-valuea | |
Age (years) | ||||||
<30 | 27 | 183 (131, 255) | 0.25 | 29 | 9.82 (8.35, 11.54) | 0.10 |
30–34 | 26 | 133 (94, 186) | 28 | 8.21 (6.96, 9.68) | ||
≥35 | 34 | 190 (141, 257) | 37 | 10.36 (8.98, 11.96) | ||
Raceb | ||||||
Caucasian | 68 | 157 (128, 193) | 0.04 | 71 | 9.28 (8.35, 10.32) | 0.71 |
African American | 9 | 286 (163, 501) | 13 | 11.23 (8.77, 14.38) | ||
Hispanic | 4 | 262 (113, 608) | 4 | 9.55 (6.11, 14.92) | ||
Asian | 5 | 88 (41, 187) | 5 | 8.86 (5.94, 13.2) | ||
Education | ||||||
<College degree | 13 | 254 (157, 410) | 0.07 | 15 | 11.56 (9.23, 14.48) | 0.06 |
≥College graduate | 74 | 157 (128, 192) | 79 | 9.16 (8.31, 10.11) | ||
Smoking status | ||||||
Never | 60 | 162 (129, 204) | 0.43 | 65 | 9.96 (8.93, 11.11) | 0.24 |
Former | 23 | 169 (117, 244) | 24 | 8.33 (6.96, 9.96) | ||
Current | 4 | 294 (122, 706) | 5 | 9.85 (6.65, 14.59) | ||
Body mass index (kg/m2) | ||||||
<25 | 64 | 150 (121, 186) | 0.04 | 67 | 9.45 (8.48, 10.54) | 0.84 |
≥25 | 23 | 234 (164, 335) | 27 | 9.65 (8.13, 11.45) | ||
Physical activityc | ||||||
Light | 25 | 206 (145, 292) | 0.28 | 27 | 10.94 (9.26, 12.93) | 0.08 |
Moderate | 40 | 167 (127, 220) | 43 | 9.39 (8.22, 10.72) | ||
Heavy | 22 | 136 (94, 198) | 24 | 8.31 (6.96, 9.92) | ||
Aspirin used | ||||||
No | 59 | 176 (140, 221) | 0.52 | 63 | 8.78 (7.88, 9.78) | 0.01 |
Yes | 28 | 154 (111, 215) | 31 | 11.18 (9.59, 13.05) | ||
Serum α-carotene (μg/dl) | ||||||
<5.1 | 27 | 266 (195, 363) | 0.001 | 31 | 9.92 (8.45, 11.65) | 0.74 |
5.1–8.35 | 27 | 172 (126, 234) | 30 | 9.08 (7.71, 10.69) | ||
>8.35 | 30 | 115 (86, 154) | 30 | 9.43 (8.01, 11.1) | ||