Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women

Table 2 Geometric mean concentrations of urinary biomarkers of oxidative stress by endogenous antioxidant defense genotypes

Genotype	8-isoprostane F2_α (pg/ml)					8-oxo-7,8-dihydro-2′-deoxyguanosine (pmol/ml)
Genotype	N	Unadjusted mean (95% CI)	p-trend^a	Adjusted mean^b (95% CI)	p-trend^a	n	Unadjusted mean (95% CI)	p-trend^a	Adjusted mean^c (95% CI)	p-trend^a
SOD Val¹⁶Ala
Val/Val	26	156 (107, 229)	0.55	159 (103, 244)	0.49	28	9.47 (7.83, 11.47)	0.42	10.02 (8.03, 12.49)	0.75
Ala/Val	40	200 (152, 263)		202 (145, 282)		43	9.72 (8.48, 11.15)		10.27 (8.58, 12.29)
Ala/Ala	21	138 (98, 194)		190 (128, 284)		22	9.18 (7.75, 10.87)		9.38 (7.58, 11.61)
CAT-262C > T
CC	57	179 (142, 226)	0.28	217 (159, 297)	0.11	62	9.33 (8.33, 10.44)	0.25	9.99 (8.61, 11.58)	0.10
TC	27	158 (112, 221)		167 (117, 239)		28	9.55 (8.07, 11.29)		10.36 (8.49, 12.63)
TT	3	101 (37, 277)		70 (28, 172)		3	13.13 (7.86, 21.94)		15.39 (9.07, 26.12)
GPX Pro¹⁹⁸Leu
Pro/Pro	45	152 (117, 197)	0.62	166 (120, 229)	0.58	46	9.71 (8.53, 11.04)	0.65	10.23 (8.49, 12.34)	0.69
Leu/Pro	32	209 (154, 285)		240 (164, 351)		35	10.22 (8.82, 11.84)		10.75 (8.86, 13.05)
Leu/Leu	10	136 (78, 236)		188 (114, 310)		10	6.92 (5.26, 9.13)		8.07 (6.00, 10.86)

^a P-value for monotonic dose–response trend from linear regression analysis in which the genotype was coded as a continuous variable (0, 1, 2)
^bAdjusted for age, race, body mass index, education level, smoking status, physical activity, serum α-carotene, and batch
^cAdjusted for age, race, body mass index, education level, smoking status, physical activity, aspirin use, and batch

ISSN: 1865-3499