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Table 5 Relative affinity of anthocyanins and phenolic acids for ERα and ERβ

From: Potential anti-inflammatory, anti-adhesive, anti/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites

Compound ERα IC50 (μM)* ERβ IC50 (μM)*
Delphinidin-3-O-glucoside NA 63.2 ± 0.8
Pelargonidin-3-O-glucoside 61.3 ± 0.7 93.0 ± 0.8
Peonidin-3-O-glucoside 64.4 ± 0.9 NA
Malvidin-3-O-glucoside NA NA
Cyanidin-3-O-glucoside NA NA
Gallic acid NA 100.3 ± 0.9
Protocatechuic acid NA NA
Syringic acid NA NA
Vanillic acid NA NA
  1. * IC50 is defined as the concentration required to achieve 50% inhibition in the binding of [3H]-estradiol to the corresponding estrogen receptor (ER). NA not achieve binding at the assayed concentration. IC50 values are shown as mean ± SD